阿魏酸钠联合双黄连注射液对病毒性心肌炎患者临床疗效及血清基质金属蛋白酶、锌铜水平的影响  

Effect of Sodium Ferulic Acid Combined with Shuang Huang Lian Injection on the Clinical Efficacy and serum Matrix Metalloproteinases, Zinc and Copper Levels of Patients with Viral Myocarditis

作　　者：陈亚伟[1] 彭道地[2] 李绍冰[3] 黄忠[1] 邸杰[1] 张欣欣[1] 

机构地区：[1]保定市第一中心医院心内科,河北保定071000 [2]中南大学湘雅医院心内科,湖南长沙410008 [3]河北省人民医院心内科,河北石家庄050057

出　　处：《现代生物医学进展》2017年第17期3335-3338,共4页Progress in Modern Biomedicine

基　　金：河北省自然科学基金项目(C2009001232)

摘　　要：目的:探究阿魏酸钠联合双黄连注射液对病毒性心肌炎患者临床疗效及血清基质金属蛋白酶、锌铜水平的影响。方法:选择在我院确诊为病毒性心肌炎的患者39例,随机分成实验组以及对照组。对照组18例给予阿魏酸钠治疗;实验组21例予阿魏酸钠联合双黄连注射液治疗。治疗14天后,评价和比较两组患者的临床疗效、心肌酶谱水平、血清基质金属蛋白酶水平及血清锌铜比值。结果:实验组总有效率为95.2%,显著高于对照组(72.2%),差异具统计学意义(P<0.05)。与对照组比,实验组治疗后的血清、乳酸脱氢酶(LDH)水平、肌酸磷酸激酶同工酶(CK-MB)、天冬氨酸氨基转移酶(AST)、基质金属蛋白酶水平较低,血清铜锌比值较小,而左室射血分数(LVEF)水平较高,差异均具有统计学意义(P<0.05)。结论:阿魏酸钠联合双黄连注射液治疗病毒性心肌炎患者能够有效提高其临床疗效,可能与其显著降低血清基质金属蛋白酶及铜锌水平有关。Objective： To investigate the effect of sodium ferulic acid combined with shuanghuanglian on the serum levels of ma- trix metalloproteinases, serum zinc and copper and clinical efficacy on the treatment of viral myocarditis. Methods： 39 patients with viral myocarditis from our hospital were selected and randomly divided into the control group and the experiment group. 18 cases in the control group were treated with sodium ferulic acid and 21 cases in the experiment group were treated with sodium ferulic acid combined with shuanghuanglian injection. Then the clinical efficacy, the serum levels of myocardial enzyme, matrix metalloproteinases and serum zinc copper ratio changes were observed and compared between two groups before and after the treatment. Results： The total effective rate of the experimental group was 72.2%, which was higher than 95.2% of the control group, and the difference was statistically significant （P〈0.05）; Compared with the control group, the serum levels of matrix metalloproteinases, copper and zinc ratio were lower the levels of lactate dehydrogenase （LDH）, creatine kinase isoenzyme （CK-MB） and aspartate aminotransferase （AST） were lower, while the left ventricular ejection fraction （LVEF） was higher in the experiment group, and the differences were statistically significant （P〈0.05）. Con- clusions： Sodium ferulate combined with shuanghuanglian injection has better clinical effects on the treatment of viral, which can effectively improve the symptoms, the heart function and clinical efficacy, and decrease the levels of matrix metalloproteinases and copper zinc ratio.

关 键 词：病毒性心肌炎 阿魏酸钠 双黄连注射液 基质金属蛋白酶 锌 铜 

分 类 号：R542.21[医药卫生—心血管疾病]