西地那非联合苁蓉益肾颗粒治疗2型糖尿病性勃起功能障碍的疗效及安全性分析  

Efficacy and safety analysis of sildenafil combined with congrong Yishen granules on patients with type 2 diabetes mellitus and erectile dysfunction

作　　者：费夏玮[1] 李慧峰[1] 吴振启[1] 颜伟[1] 陈瑛[1] 

机构地区：[1]复旦大学附属中山医院青浦分院泌尿外科,上海201700

出　　处：《中国性科学》2017年第5期11-14,共4页Chinese Journal of Human Sexuality

基　　金：复旦大学附属中山医院青浦分院院级科研项目(QY2017-05)

摘　　要：目的:探讨西地那非联合苁蓉益肾颗粒治疗2型糖尿病性勃起功能障碍(erectile dysfunction,ED)的疗效及安全性分析。方法:将70例二甲双胍药物控制的2型糖尿病性ED患者随机分为A、B两组,A组35例,服用西地那非;B组35例,联合服用西地那非和苁蓉益肾颗粒,两组均治疗4周。分别对治疗前后国际勃起功能指数-5评分(international index of erectile function,IIEF-5)、每周性交频率、夫妻双方性生活满意程度进行统计分析,并观察两组患者治疗期间的不良反应。结果:A、B两组在IIEF-5评分、每周性交频率、夫妻双方性生活满意程度方面均较治疗前增加,差异具有统计学意义(P<0.05),但B组治疗后在IIEF-5评分、夫妻双方性生活满意程度高于A组治疗后,差异具有统计学意义(P<0.05)。两组患者治疗期间未发生严重不良反应。结论:西地那非联合苁蓉益肾颗粒治疗2型糖尿病性ED较单用西地那非可显著改善患者的勃起功能,提高夫妻性生活质量,安全、有效。Objectives： To observe the efficacy and safety of sildenafil combined with congrongyishen granules for the treatment of patients with erectile dysfunction（ ED） and type 2 diabetes mellitus. Methods： A total of70 ED patients with type 2 diabetes mellitus were randomly divided into 2 groups. Group A（ 35 patients） was given sildenafil treatment alone for 4 weeks and Group B（ 35 patients） was treated with sildenafil combined with congrongyishen granules for 4 weeks. Before and after the treatment,the mean international index of erectile function-5（ IIEF-5）,sexual intercourse frequency each week,intercourse satisfaction and the drug adverse effect of patients were evaluated. Results： After treatment,both groups had significant increases in IIEF-5,sexual intercourse frequency each week and intercourse satisfaction（ P〈0. 05）. The increase of IIEF-5 and intercourse satisfaction in Group B was more significant than that in Group A（ P〈0. 05）. No adverse events were noted in the two groups. Conclusion： Compared to sildenafil therapy only,sildenafil combined with congrongyishen granules can improve the sexual function of ED patients with type 2 diabetes mellitus,leading to a satisfactory sexual life.

关 键 词：苁蓉益肾颗粒 勃起功能障碍 PDE5抑制剂 西地那非 2型糖尿病 

分 类 号：R587.2[医药卫生—内分泌]