左炔诺孕酮宫内缓释系统联合子宫内膜息肉切除术治疗子宫内膜息肉的效果评价  

Effect of levonorgestrel-releasing intrauterine system combining transcervical resection of polyp on levels of hemoglobin and sex hormone

作　　者：李立丽[1] 蒋维[2] 韩炜[2] 

机构地区：[1]冀中能源邢台矿业集团有限责任公司总医院妇科,河北邢台054000 [2]唐山市妇幼保健院妇产科,河北唐山063000

出　　处：《中国性科学》2017年第5期46-49,共4页Chinese Journal of Human Sexuality

基　　金：2016年河北省卫计委医学科学研究重点课题(20160828)

摘　　要：目的:探究左炔诺孕酮宫内缓释系统联合子宫内膜息肉切除术治疗子宫内膜息肉效果评价。方法:选择2013年6月至2015年6月期间264例子宫内膜息肉患者为研究对象,根据入院时间分为观察组和对照组各132例。对照组行子宫内膜息肉切除术,观察组于子宫内膜息肉切除术后放置左炔诺孕酮宫内缓释系统,比较两组血红蛋白、性激素水平、子宫内膜厚度、临床疗效等指标。结果:观察组有效率90.15%明显高于对照组75.00%,复发率7.58%明显低于对照组20.45%(χ~2=10.531、9.084,P<0.05);治疗6个月,观察组血红蛋白水平明显高于对照组察组(t=26.363,P<0.05);两组卵泡刺激素(FSH)、黄体酮激素(LH)、孕酮(P)、雌二醇(E_2)比较无统计学意义(P<0.05);腺上皮与间质雌激素受体(ER)、孕激素受体(PR)均明显低于对照组(t=5.337、12.319、5.477、12.488,P<0.05);子宫内膜厚度、子宫重量明显低于对照组(t=9.874、9.439,P<0.05)。结论:左炔诺孕酮宫内缓释系统联合子宫内膜息肉切除术有助于改善子宫内膜息肉患者善贫血症状,下调雌、孕激素表达水平,抑制子宫内膜过度增生,降低复发率,提高临床疗效。Objectives： To study the effect of levonorgestrel releasing intrauterine system combined with tran- scervical resection of polyp in the treatment of endometrial polyps （EMP）. Methods： 264 patients with EMP admitted to hospital from June 2013 to June 2015 were selected and divided into observation group and control group according to the admission time, with 132 eases in each group. Patients in the control group were performed transeervical resec- tion of polyp, and patients in the observation group were given levonorgestrel releasing intrauterine system after theperforming of transcervical resection of polyp. The hemoglobin level, level of sex hormone, endometrial thickness, clinical efficacy and other indexes of the two groups were compared. Results： The effective rate of the observation group （90. 15% ） was significantly higher than that of the control group （75.00%） ; the recurrence rate （7.58%） was significantly lower than that of the control group （20. 45% ） （X2 = 10. 531, 9. 084, P 〈0. 05）. After 6 months＇ treatment, the hemoglobin level of the observation group was significantly higher than that of the control group （ t = 26. 363, P 〈 0. 05 ）. The differences in levels of follicle - stimulating hormone （ FSH）, luteohormone （ LH）, proges- terone （P） and estradiol （ E2 ） between the two groups were not statistically significant （ P 〈 0. 05 ）. The levels of glandular epithelium and mesenchymal estrogen receptor （ER） and progesterone receptor （PR） were significantly low- er than those of the control group （t =5. 337, 12. 319, 5. 477, 12. 488, P 〈0. 05）. The endometrial thickness and womb weight were significantly lower than those of the control group （ t = 9. 874, 9. 439, P 〈 0. 05 ）. Conclusion ： Levonorgestrel - releasing intrauterine system combining transcervical resection of polyp is conductive to improving the anemia symptoms of patients with EMP, downregulate the expression levels of estrogen and progestational hormone,

关 键 词：左炔诺孕酮宫内缓释系统 子宫内膜息肉切除术 血红蛋白 性激素 子宫内膜厚度 

分 类 号：R711.74[医药卫生—妇产科学]