创伤后应激障碍门诊患者脑内神经递质的活动情况  

Brain neurotransmitters in outpatients with posttraumatic stress disorder by EEG slow fluctuation map technique

作　　者：钟浩[1] 郑龙[2] 马文涛[2] 

机构地区：[1]陕西中医药大学第一临床医学院,陕西咸阳712000 [2]中国人民解放军第三医院全军精神卫生中心,陕西宝鸡721004

出　　处：《职业与健康》2017年第6期861-864,共4页Occupation and Health

基　　金：兰州军区医药卫生科研项目(CWS10JA03)

摘　　要：目的探讨不同年龄和性别创伤后应激障碍门诊患者脑内神经递质的活动情况。方法随机选取74例门诊创伤后应激障碍门诊患者,利用脑电超慢涨落图技术(ET)对其进行检测,分析不同年龄、性别创伤后应激障碍患者脑内神经递质γ-氨基丁酸(GABA)、谷氨酸(Glu)、乙酰胆碱受体(Ach R)、5-羟色胺(5-HT)、乙酰胆碱(Ach)、强兴奋介质(EXC)、去甲肾上腺素(NE)、多巴胺(DA)、深抑制介质(INH)的及其相关神经递质比值的差异。结果各年龄段实测值与正常值比较,13~29岁年龄段,GABA、DA实测值显著低于正常值(P<0.05),Ach、INH实测值显著高于正常值(P<0.01或P<0.05);39~49岁年龄段,Ach R实测值显著高于正常值(P<0.05);49~59岁年龄段,GABA实测值显著低于正常值(P<0.05);59~69岁年龄段中,EXC实测值显著低于正常值(P<0.05)。各年龄段神经递质比较,Glu实测值在各组间有统计学意义(P<0.05),49~59岁年龄段与13~29岁年龄段、39~49岁年龄段分别在Ach、INH实测值上差异有统计学意义(均P<0.05),而59~69岁年龄段与39~49岁年龄段在EXC实测值上差异有统计学意义(P<0.05)。不同性别神经递质比较,在GABA、5-HT、DA检测值上差异有统计学意义。结论不同年龄段创伤后应激障碍患者兴奋与抑制性神经递质有所差异。[ Objective] To explore the activity of brain neurotransmitters in outpatients with posttraumatic stress disorder by using EEG slow fluctuation map technique. [Methods] 74 outpatients with posttraumatic stress disorder were randomly selected and detected by the EEG slow fluctuation map technique （ET）. The differences in levels of brain neurotransmitters, including gamma aminobutyric acid （GABA）, glutamate （Glu）, aeetyleholine receptor （AchR）, serotonin （5-HT）, acetylcholine （Ach）, strongly excited medium （EXC）, norepinephrine （NE）, dopamine （DA）, deep suppression medium （INH）, and ratios of related neuro- transmitters among different age, gender groups were analyzed. [Results] In 13-29 year-old age group, the measured values of GABA and DA were significantly lower than normal values （P〈0.05）, the measured values of Ach and INH were significantly higher than normal values （P〈0.01 or P〈0.05）. In 39-49 year-old age group, the measured value of AchR was significantly higher than normal value （P〈0.05）. In 49-59 year-old age group, the measured value of GABA was significantly lower than normal value （P〈0.05）. In 59-69 year-old age group, the measured value of EXC was significantly lower than normal value （P〈0.05）. The difference in the measured value of Glu was statistically significant among age groups （P〈0.05）. There were statistically significant differences in the measured values of Ach and INH among 49-59 and 13-29, 39-49 year-old age groups （allP〈0.05 ）, while the difference in the measured value of EXC was statistically significant between 59-69 and 39-49 year-old age groups （P〈0.05）. There were statistically significant differences in the measured values of GABA, 5-HT and DA between sex groups.[ Conclusion] There are differences in the excitatory and inhibitory neurotransmitters among age groups of patients with posttraumatic stress disorder, which may be related to the sensitivity to stress events of different ages.

关 键 词：创伤后应激障碍 神经递质 脑电超慢涨落图 

分 类 号：R444[医药卫生—诊断学]