舒血宁联合哌拉西林/舒巴坦在2型糖尿病合并下呼吸道感染患者中的应用效果  

Effect of Shuxuening combined with piperacillin-sulbactam on treatment of type 2 diabetes mellitus patients complicated with lower respiratory tract infections

作　　者：孙殿静[1] 代晓茹[1] 刘晴晴[1] 张雪坤[1] 耿建林[1] 

机构地区：[1]衡水市哈励逊国际和平医院内分泌科,河北衡水053000

出　　处：《中华医院感染学杂志》2017年第10期2229-2232,共4页Chinese Journal of Nosocomiology

基　　金：河北省衡水市科技支撑计划基金资助项目(15024)

摘　　要：目的探讨舒血宁联合哌拉西林/舒巴坦在2型糖尿病合并下呼吸道感染患者中的应用效果。方法选取2013年6月-2016年6月于医院进行治疗的2型糖尿病合并下呼吸道感染患者86例,随机分为联合用药组与对照组,各43例;对照组患者在常规治疗基础上给予舒血宁注射液,联合用药组在对照组基础上联合应用哌拉西林/舒巴坦钠;对所有下呼吸道感染患者进行病原菌分析,并对比两组患者的疗效、炎性因子、用力肺活量(FVC)、一秒用力呼气容积(FEV1)及不良反应发生率。结果 86例2型糖尿病合并下呼吸道感染患者共分离出病原菌95株,其中革兰阴性菌60株占63.2%,革兰阳性菌31株占32.6%,真菌4株占4.2%;联合用药组2型糖尿病合并下呼吸道感染患者治疗总有效率为93.0%,显著高于对照组67.4%(P<0.05);治疗前,两组2型糖尿病合并下呼吸道感染患者的炎性因子水平、FEV1/FVC差异无统计学意义;治疗后,两组患者的炎性因子水平均得以显著降低(P<0.01),联合用药组炎性因子显著低于对照组(P<0.01),两组患者的FEV1/FVC均得以显著升高(P<0.01),联合用药组FEV1/FVC显著高于对照组(P<0.01),联合用药组2型糖尿病合并下呼吸道感染患者不良反应发生率为9.3%,对照组为11.6%,两组比较差异无统计学意义。结论舒血宁联合哌拉西林/舒巴坦治疗2型糖尿病合并下呼吸道感染临床疗效较好,可以显著降低C-反应蛋白、B型脑钠肽与降钙素原水平,改善肺功能,安全性较高。OBJECTIVE To explore the effect of Shuxuening combined with piperacillin-sulbactam on treatment of type 2 diabetes mellitus patients complicated with lower respiratory tract infections.METHODS A total of 86 type 2 diabetes mellitus patients complicated with lower respiratory tract infections who were treated in the hospital from Jun 2013 to Jun 2016 were enrolled in the study and randomly divided into the combined treatment group and the control group,with 43 cases in each group.The control group was given Shuxuening injection on the basis of conventional therapy,while the combined treatment group was treated with piperacillin-sulbactam on the basis of the treatment of the control group.The pathogens isolated from the patients with lower respiratory tract infection were identified.The efficacy,inflammatory factors,forced vital capacity （FVC）,forced expiratory volume in 1 second （FEV1）,and incidence of adverse reactions were observed and compared between the two groups of patients.RESULTS Totally 95 strains of pathogens were isolated from the 86 type 2 diabetes mellitus patients complicated with lower respiratory tract infections,of which 60 （63.2%） were gram-negative bacteria,31 （32.6%）were gram-positive bacteria,and 4 （4.2 %） were fungi.The total effective rate of treatment of the type 2 diabetes mellitus patients complicated with lower respiratory tract infections was 93.0% in the combined treatment group,remarkably higher than 67.4% in the control group （P〈0.05）.There was no significant difference in the levels of inflammatory factors or FEV1/FVC between the two groups of patients before the treatment.The levels of inflammatory factors of the two groups of patients were significantly reduced after the treatment（P〈0.01）,and the levels of inflammatory factors of the combined treatment group were significantly lower than those of the control group （P〈0.01）.The FEV1/FVC of the two groups of patients was significantly increased （P〈0.01）,and the FEV1/FVC of the combined tr

关 键 词：舒血宁 哌拉西林/舒巴坦 2型糖尿病 下呼吸道感染 

分 类 号：R587.1[医药卫生—内分泌]