维持性血液透析患者血尿酸水平与心血管疾病的相关性  

Correlation between serum uric acid and cardiovascular disease in maintenance hemodialysis patients

作　　者：王柳雯[1] 李萍华[2] 汤日祥 

机构地区：[1]柳州市人民医院肾内科,广西柳州545001 [2]深圳市龙岗区人民医院肾内科,广东深圳510270 [3]东莞市大岭山医院内科,广东东莞523820

出　　处：《海南医学》2017年第9期1413-1415,共3页Hainan Medical Journal

摘　　要：目的探讨维持性血液透析(MHD)患者血尿酸水平与心血管疾病的相关性。方法选择我院血液净化室在2012年1月至2015年12月期间治疗的72例MHD患者为研究对象,根据血尿酸水平将患者分别纳入正常尿酸组(n=25)和高尿酸组(n=47),比较两组患者的超声心动图心脏结构及功能指标,并比较心血管疾病(CVD)的发病率。结果本组72例MHD患者中高尿酸血症发生率为65.28%;高尿酸组患者左心室舒张末内径(LVEDD)为(53.13±5.55)mm,明显高于正常尿酸组的(47.38±6.21)mm,舒张早期及晚期最大血流速度比(E/A)、左室射血分数(LVEF)分别为(1.07±0.23)、(51.24±5.32)%,明显低于正常尿酸组的(56.12±6.21)%,差异均有统计学意义(P<0.05);高尿酸组患者CVD发生率为63.83%,明显高于正常尿酸组的40.00%,差异有统计学意义(P<0.05)。结论血尿酸水平能反映MHD患者心脏结构和功能的变化,对MHD患者左心室肥厚和功能的评估具有重要价值,并且血尿酸水平与心血管疾病的发生关系密切。Objective To investigate the correlation between serum uric acid level and cardiovascular disease in maintenance hemodialysis（MHD） patients. Methods From January 2012 to December 2015, 72 MHD patients in Blood Purification Room of our hospital were selected as research objects. According to the level of blood uric acid, they were divided into normal uric acid group（n=25） and high uric acid group（n=47）. Echocardiography in cardiac structure and function, and cardiovascular disease（CVD） rate in two groups were compared. Results In the 72 cases, the hyperuricemia rate was 65.28%. Left ventricular end-diastolic diameter（LVEDD） in high uric acid group were（53.13±5.55） mm,significantly higher than（47.38 ± 6.21） mm in the normal uric acid. Left ventricular ejection fractions（LVEF） were（51.24±5.32）%, significantly lower than（56.12±6.21）% in normal uric acid group（P〈0.05）. CVD rate in high uric acid group was 63.83%, significantly higher than 40.00% in normal uric acid group（P〈0.05）. Conclusion Serum uric acid level can reflect the changes of cardiac structure and function in patients with MHD, which is of great value in the evaluation of left ventricular hypertrophy and function in patients with MHD, and is closely related to the occurrence of cardiovascular disease.

关 键 词：血液透析 高尿酸血症 心血管疾病 相关性 

分 类 号：R459.5[医药卫生—治疗学]