老年人群24小时动态血压变异性与肾功能损害的关系  

Relationship between 24-hour ambulatory blood pressure variability and renal dysfunction in the elderly

作　　者：王秀艳[1] 宋路 刘春红[1] 吴寿岭[1] 王玉珍[1] 

机构地区：[1]开滦总医院老年病科,河北省唐山市063000 [2]华北理工大学研究生院,河北省唐山市063000

出　　处：《中国动脉硬化杂志》2017年第5期509-512,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨老年人群24 h动态血压变异性与肾功能损害的关系。方法在参加开滦研究队列第三次健康体检的人群中,采取整群抽样的方法随机抽取3064例年龄≥60岁的开滦集团离退休员工,对其进行动态血压监测,最终纳入统计分析的为1382例。根据动态收缩压的标准差(SSD)四分位数将调查人群分为四组,测定各项生化指标,计算肾小球滤过率(eGFR),采用秩相关分析和逐步线性回归模型分析SSD与eGFR的关系。结果在1382例观察对象中,平均年龄为67.16±5.86岁,其中,男性905例(65.5%),女性477例(34.5%)。24h SSD、日间SSD和夜间SSD均与eGFR呈负相关;对e GFR的影响因素进行逐步线性回归分析,校正其他混杂因素后,24h SSD、日间SSD仍与e GFR呈负线性相关。结论 24h SSD和日间SSD与eGFR呈负线性相关。Aim To investigate the relationship between 24-hour ambulatory blood pressure variability （BPV） and renal dysfunction in the elderly. Methods In the third physical examination for Kailuan Group, the method of cluster sampling was adopted to randomly draw 3064 retired employees（≥60 years old）, with 24-hour ambulatory blood pressure monitoring. Finally, 1382 participants with integral data were recruited into the survey. The elderly were divided into four groups by quartile of the standard deviation of systolic blood pressure （SSD）. Biochemical index was recorded. The estimated glomerular filtration rate （eGFR） was calculated. The effect of SSD on kidney function was analyzed using rank correlation analysis and stepwise linear regression model. Results Among 1382 participants （67.16±5.86 years old）, 905 individuals were male and 477 were female. Rank correlation analysis confirmed that there was a significant negative correlation between eGFR levels and 24hSSD, daytime SSD, nighttime SSD. Stepwise linear regression analysis indicated that there was a significant negative linear correlation between eGFR and 24hSSD, daytime SSD after adjustment for other risk factors. Conclusion There was a significant negative linear correlation between eGFR levels and 24hSSD, daytime SSD.

关 键 词：老年人群 血压变异性 肾小球滤过率 收缩压标准差 

分 类 号：R18[医药卫生—流行病学]