胺碘酮用于腹部外科术后心房颤动复律的量效关系  

作　　者：林敬阳[1] 郑小春[1] 

机构地区：[1]浙江省人民医院(杭州医学院附属人民医院),310014

出　　处：《浙江临床医学》2017年第6期1074-1075,共2页Zhejiang Clinical Medical Journal

摘　　要：目的对比观察静脉注射不同负荷剂量胺碘酮对行腹部外科术后发作阵发性心房纤颤的患者转为窦性心律的量效关系与安全性。方法28例腹部外科术后发作阵发性心房纤颤患者随机分成胺碘酮150mg负荷量组（14侧）和胺碘酮300mg负荷量组（14例）。观察10min、6h、24h内房颤转为窦律的比率和不良反应率。结果胺碘酮150mg负荷量组10min内转律1例，6h内总转律6例，24h内总转律10例．胺碘酮300rag负荷量组10min内转律5例，6h内转律11例，24h内转律13例。两组比较，差异有显著性。两组均未见复律后严重心动过缓、窦房和房室阻滞、窦性停搏等。结论静脉应用胺碘酮300mg负荷量组对阵发性房颤转为窦性心律的有效率优于静脉应用胺碘酮150mg负荷量组，尤其是用药10min内房颤转为窭性心律的有效率，并且不良反应无明显增加，安全、有效，值得推广。Objective To compare the efficacy and safety of converting paroxysmal atrial fibrillation to sinus rhythm in the patients which received abdominal surgery before onset paroxysmal atrial fibrillation by injecting different doses of amiodarone by intravenous. Methods 28 patients with paroxysmal atrial fibrillation after abdominal surgery were randomly divided into two groups： 150 mg amiodarone load group （ n=14 ） and 300 mg amiodarone load group （ n=14 ） . The rate of AF to sinus rhythm was observed in 10 min, 6 h, 24h. Results There was l cases in 10 minutes of 150 mg amiodarone load group, 6 cases in 6 hours and 10 cases in 24 hours. There were 5 cases in 10 minutes of 300 mg amiodarone load group, 11 cases in 6 hours and 13 cases in 24 hours. There was significant difference between the two groups. No severe sinus bradycardia, sinoatrial and atrioventricular block, sinus arrest and so on, after cardioversion. Conclusion The effects of converting paroxysmal atrial fibrillation to sinus rhythm in 300mg amiodarone loading group is better than 150mg amiodarone loading group, especially the effective rate of converting atrial fibrillation to sinus rhythm in 10 minutes after treatment, and no adverse reaction significantly increase.That is safe, effective and worthy of promotion.

关 键 词：胺碘酮 心房颤动 腹部外科术后 治疗 

分 类 号：R459.3[医药卫生—治疗学]