高催乳素血症的病因分析及其对患者生殖功能的影响  

The etiological analysis of hyperprolactinemia and its influence on reproductive function

作　　者：刘俐伶[1] 庞丽红[1] 植枝福[1] 

机构地区：[1]广西医科大学第一附属医院妇产科,南宁530021

出　　处：《广西医科大学学报》2017年第6期847-850,共4页Journal of Guangxi Medical University

基　　金：广西壮族自治区卫生厅自筹经费科研课题资助项目(No.Z2014040)

摘　　要：目的:探讨高催乳素血症(HRPL)的病因及其对患者生殖功能的影响。方法:选取2012年11月至2013年11月在广西医科大学第一附属医院就诊的78例HRPL患者为研究组,另选取同期于本院体检合格的78例健康志愿者为对照组。对研究组患者进行HRPL的病因分析及个性化治疗,比较两组血清中催乳素(PRL)、雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)的水平,采用Pearson相关分析法分析PRL与性激素E2、LH、FSH、T的相关性。随访2年,统计并比较两组妊娠率。结果:78例HRPL患者中,垂体腺瘤诱发的HRPL所占比例最高,为39.75%。研究组患者血清PRL、T水平高于对照组,血清E2、LH、FSH水平低于对照组(P<0.05)。研究组患者PRL与FSH、LH水平呈负相关关系(r=-0.358,P=0.002;r=-0.431,P=0.000),与E2、T水平无明显相关关系(r=0.137,P=0.076;r=0.128,P=0.082)。对照组累计妊娠率为89.74%,显著高于研究组的66.67%,差异有统计学意义(χ2=15.132,P=0.000)。结论:垂体腺瘤是HRPL最常见的病因,HRPL患者存在性激素紊乱,可能导致不孕不育。Objective. To explore the cause of hyperprolactinemia （HRPL） and its influence on reproductive function. Methods：78 HRPL patients treated in our hospital from November 2012 to November 2013 were enrolled as a research group, and 78 healthy volunteers as a control group at the same time. The cause and individualized treatment of HRPL were analyzed. The levels of prolactin （PRL）, estradiol （E2）, luteinizing hormone （LH）, follicle-stimulating hormone （FSH） and testosterone （T） in serum were compared between the two groups. All families were followed up for 2 years and the successful pregnancy rate was recorded. Results. Pituitary microadenoma was the most prevalent cause for HRPL （39.75%）. The levels of PRL and T were significantly higher, while the E2, LH and FSH levels in serum were markedly lower in the research group than those in the control group （P〈0.05）. The PRL was negatively correlated with FSH and LH （r=-0. 358, P = 0. 002; r= -0.431, P = 0. 000）, but not significantly associated with E2 and T （r=0.137, P=0.076; r=0.128, P=0.082）. The cumulative pregnancy rate was 89.74% in the research group, which was higher than that in the control group （66.67%） （P〈0.05）. Conclusion：Pituitary microadenoma was the most common cause of the HRPL. Sex hormone disorder is common among HRPL patients, which can lead to male and female infertility.

关 键 词：HRPL 性激素 不孕症 

分 类 号：R335.5[医药卫生—人体生理学]