链球菌感染及家庭因素与小儿抽动障碍的关系  

Relationship of streptococcal infection and family factors with tic disorder among children

作　　者：高翠琴[1] 

机构地区：[1]广东省惠州市中心人民医院儿科,惠州市516000

出　　处：《广西医学》2017年第5期615-617,共3页Guangxi Medical Journal

基　　金：广东省惠州市科学技术局科研项目(20150803)

摘　　要：目的探讨小儿抽动障碍与链球菌感染、家庭因素的关系。方法选取小儿抽动障碍患儿共60例为观察组、100例健康儿童作为对照组。检测并比较两组链球菌感染情况、血清抗DNA酶B和肿瘤坏死因子-α(TNF-α)水平,同时对两组进行相关家庭因素的问卷调查;采用logistic回归模型分析影响小儿抽动障碍发生的危险因素。结果观察组链球菌感染率为41.67%,高于对照组的18.00%(P<0.05)。观察组抗DNA酶B滴度、TNF-α水平均高于对照组(P<0.05)。对照组存在打骂体罚、孕期营养不良、任性发脾气、注意力分散、压力大、近期有感染症状者的比例高于观察组(P<0.05)。Logistic回归分析结果显示打骂体罚、孕期营养不良、高抗DNA酶B滴度、压力大和任性发脾气是小儿抽动障碍的独立危险因素(P<0.05)。结论抽动障碍与链球菌感染相关,而父母打骂、母亲孕期营养不良以及家庭环境和个性也是小儿抽动障碍发生的危险因素,在临床上应该高度重视。Objective To explore the relationship of streptococcal infection and family factors with tic disorder among children. Methods Sixty children with tic disorder were enrolled as observation group and 100 healthy children as control group. The incidence of streptococcal infection ,and the levels of serum anti-deoxyribonuclease B（ ADNase B） and tumor necrosis factors-a（TNF-α） were determined and compared between the two groups. A questionnaire survey on relevant family factors was conducted in both groups. Multivariate logistic regression model was used to analyze the risk factors for the incidence of tic disorder in children. Results The streptococcal infection rate of the observation group was 41.67% , and was higher than that of the control group （ 18.00% ; P 〈 0.05 ）. The titer of ADNase B and TNF-α level of the observation group were higher than those of the control group （ P 〈 0.05 ）. The proportions of children with scold and corporal punishment, malnutrition during pregnancy, caprice, distraction, high-stress and recent infection signs in the control group were higher than those in the observation group （P 〈 0.05 ）. Logistic regression analysis showed that scold and corporal punishment, malnutrition during pregnancy, higher ADNase B titer, high-stress and caprice were the independent risk factors for children with tic disorder（P 〈 0.05 ）. Conclusion Tic disorders is related to streptococcal infection. Scold by parents, malnourished mothers during pregnancy ,family environment and personality are also the risk factors for children with tic disorder,to which attention should be highly paid.

关 键 词：抽动障碍 链球菌感染 抗DNA酶B 家庭 危险因素 小儿 

分 类 号：R378.12[医药卫生—病原生物学] R749.17[医药卫生—基础医学]