连翘中具有抗菌活性的苯乙醇苷类化学成分研究  

Antibacterial Phenylethanoid Glycosides from Fruits of Forsythia suspensa

作　　者：姜醒[1] 鲁丽敏[1] 张春蕾[1] 王兴焱[1] 孙琦[1] 王佳天 苑光军[1] 

机构地区：[1]黑龙江中医药大学佳木斯学院,黑龙江佳木斯154007

出　　处：《中国现代中药》2017年第5期642-647,共6页Modern Chinese Medicine

基　　金：黑龙江省自然基金项目(H201464)

摘　　要：目的:研究连翘中具有抗菌活性的苯乙醇苷类化合物,探讨连翘抗菌药效物质基础。方法:采用有机溶剂提取药材,不同极性有机溶剂萃取提取液,抗菌活性跟踪结合各种色谱法,获得活性化合物。与文献报道谱学数据对比确定化合物的结构。结果:从该药材中分离获得9个化合物,分别鉴定为6'-O-(顺式-1,4-二羟基环己乙酰基)-类叶升麻苷(1),4-O-鼠李糖基-7S,8R-7',8'-赤式-蒜芥茄脂素(2),毛花球花苷A(3),黄花马缨丹苷B(4),石蚕苷B(5),紫茎女贞苷J(6),厚朴苷F(7),松果菊苷(8),异厚叶车前苷(9)。化合物1、6、8对金黄色葡萄球菌(ATCC 33591)生长具有中等强度抑制作用,MIC值分别为8.0、16.0、4.0μg·m L-1。结论:8个苯乙醇苷类化合物(1,3~9)和1个木脂素类化合物(2)系首次从该植物中获得。Objective： To Study on the antibacterial phenylethanoids from the fruits of Forsythia suspensa. Methods： The plant materials were extracted with organic solvent. The extract was extracted by different polarity organic solvents a- gain. Compounds were obtained by comprehensive chromatography. The structures were identified by NMR. Results： Nine com- pounds were isolated and identified from the fruits of F. suspensa, including 6＇-O-（ cis-1, 4-dihydroxycyclohexanacetyl）-acte- oside （1）, 4-O-rhamnosyl-7S, 8R-7＇, 8＇-erythro-sisymbrifolin （2）, trichosanthoside A （3）, fueatoside B （4）, poliumo- side B （5） , ligupurpuroside J （6） , magnoloside F （7） , echinacoside （8） , and isoerassifolioside （9）. Compounds 1, 6, 8 showed antibacterial activity against Staphylococcus aureus with MICs of 8.0, 16.0 and 4.0 μg mL-1, respectively. Conclusion：Eight phenylethanoide glycosides （1, 3-9） and a neolignan （2） were obtained from the plant firstly.

关 键 词：连翘 苯乙醇苷类化合物 抗菌活性 

分 类 号：R282.71[医药卫生—中药学]