不同道地产区大黄功效组分含量的差异分析  

Analysis on Functional Components Content of Radix et Rhizoma Rhei in Different Geo-authentic Habitat

作　　者：刘佳[1] 李莉[2,3] 胡会娟 商彤[1] 孟磊[1] 李永杰[1] 魏胜利[1,4] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]首都医科大学附属北京中医医院,北京100035 [3]北京市中药研究所,北京100035 [4]中药材规范化生产教育部工程研究中心,北京100102

出　　处：《中国现代中药》2017年第5期662-669,共8页Modern Chinese Medicine

基　　金：国家自然科学基金项目(31570331;31170307);国家工信部项目(YC12TY-1QT0007);北京中医药大学自主选题(2016-JYB-XS071)

摘　　要：目的:分析大黄8个道地产区4种功效组分(游离蒽醌类、结合蒽醌类、酚酸类和二蒽酮类)14种活性成分的含量和比例差异,为研究其在"清热解毒、泻下攻积、逐淤通经"三种功效活性上的潜在优势提供参考。方法:采用HPLC进行含量测定,利用SPSS进行方差分析。结果:不同道地产区大黄4种功效组分含量之间差异有统计学意义(P<0.05)。其中,游离蒽醌类物质含量以铨水大黄最高,西宁大黄和河州大黄次之;结合蒽醌和二蒽酮类成分含量以庄浪大黄最高,西宁大黄和雅黄次之;而酚酸类物质含量最高的为凉黄,西宁大黄和铨水大黄次之。结论:结合不同成分的药理学活性,铨水大黄、西宁大黄和河州大黄在清热解毒功效上具有潜在优势,庄浪大黄、西宁大黄和雅黄在泻下攻积功效上具有潜在优势,而同时西宁大黄、铨水大黄和凉黄在逐瘀通经功效上具有潜在优势,上述结果对于指导大黄精准用药具有重要意义。Objective： To study the difference of contents and proportions of 4 kinds of functional components （ free an- thraquinones, combined anthraquinones, phenolic acids and bianthrone） in 14 kinds of active components of Radix et Rhizoma Rhei in 8 kinds of different geo-authentic habitat, evaluates indirectly the difference of ＂diarrhea under the plot, heat-clearing and detox- ifying, by silt through＂ 3 functional activity. Methods： The contents of the components was determined by HPLC, variance was an- alyzed by SPSS. Results： Between different geo-authentic habitat of Radix et Rhizoma Rhei, 4 kinds of functional components were all significantly different （P 〈0. 05）. Among them, the highest content of free anthraquinones was Quanshni Radix et Rhizoma Rhei, the second were Xining and Hezhou Radix et Rhizoma Rhei; the highest content of combined anthraquinones and bianthrone was Zhuanglang Radix et Rhizoma Rhei, the second were Xining and Ya Radix et Rhizoma Rhei; the highest content of phenolic acids was Liang Radix et Rhizoma Rhei, the second were Xining and Quanshui Radix et Rhizoma Rhei. Conclusion： Combining the phar- macological activity of different components, Quanshui, Xining and Hezhou Radix et Rhizoma Rhei could all be potential special medicinal germptasm that have function of active blood circulation to dissipate blood stasis; Zhuanglang, ）Lining and Ya Radix et Rhizoma Rhei could all be potential specialmedicinal germplasms that exist diarrhea attack characters; Xining, Quanshui and Liang Radix et Rhizoma Rhei could all be potential special medicinal germplasm that activate blood circulation to dissipate blood stasis. The above results are of great significance for the accurate use of Radix et Rhizoma Rhei.

关 键 词：道地药材 大黄 活性成分 功效组分 

分 类 号：R284.1[医药卫生—中药学]