决明降脂片与多烯磷脂酰胆碱胶囊治疗非酒精性脂肪肝的临床研究  

Clinical trial of polyene phosphatidylcholine capsule combined with Jueming Jiangzhi tablets in the treatment of non-alcoholic fatty liver disease

作　　者：竺狄芳 赵白云[1] 朱梦飞[2] 

机构地区：[1]杭州师范大学附属医院药学部,杭州310015 [2]杭州师范大学附属医院肝科外科,杭州310015

出　　处：《中国临床药理学杂志》2017年第10期942-944,共3页The Chinese Journal of Clinical Pharmacology

基　　金：浙江省自然科学基金资助项目(LQ16H290003)

摘　　要：目的观察多烯磷脂酰胆碱胶囊联合决明降脂片治疗非酒精性脂肪肝临床疗效及安全性。方法 62例非酒精性脂肪肝患者随机分为对照组31例与试验组31例。对照组给予多烯磷脂酰胆碱胶囊456 mg,每日3次,口服;试验组在对照组的基础上给予决明降脂片2.7 g,每日3次,口服。2组患者均治疗2个月。比较2组患者的临床疗效、瘦素、肝功能水平及药物不良反应发生情况。结果治疗后,试验组总有效率为87.10%(27/31例),对照组为64.52%(20/31例,P<0.05)。治疗后,对照组和试验组血清瘦素分别为(1.08±0.17),(0.76±0.89)μg·L^(-1),谷丙转氨酶分别为(50.82±5.59),(34.97±4.03)U·L^(-1),谷草转氨酶分别为(54.92±6.02),(40.25±4.53)U·L^(-1),总胆红素分别为(30.11±3.35),(27.89±3.09)μmol·L^(-1),直接胆红素分别为(18.02±2.01),(13.60±1.67)μmol·L^(-1),白蛋白分别为(35.92±4.45),(42.03±4.70)g·L^(-1),差异均有统计学意义(P<0.05)。试验组出现的药物不良反应有轻微胃肠道紊乱、眩晕头痛、皮疹,药物不良反应发生率为9.68%(3/31例);对照组出现的药物不良反应有眩晕头痛、眩晕头痛、皮疹、肝硬化,药物不良反应发生率为22.58%(7/31例),2组药物不良反应率差异无统计学意义(P>0.05)。结论多烯磷脂酰胆碱胶囊联合决明降脂片治疗非酒精性脂肪肝的临床疗效较高,安全性高。Objective To evaluate the clinical efficacy and safety of polyene phosphatidylcholine capsule combined with Jueming Ji tablets in the treatment of nonalcoholic fatty liver di angzhi sease. Methods A total of 62 patients with nonalcoholic fatty liver disease were randomly divided into control group and treatment group, each group 31 cases. Patients in control group were given polyene phosphatidylcholine capsule 456 mg, three times a day. Patients in treatment group were given Jueming Jiangzhi tablets 2. 7 g, 3 times a day on the basis of control group. All patients were treated for 2 months. The clinical efficacy, leptin, level of liver function and adverse drug reactions in two groups were compared. Results After treatment, the total effective rate of treatment group was 87. 10% （27/31）, had significant difference with that in control group, which was 64. 52% （20/31 ,P 〈0. 05）. After treatment, the serum leptin in control group and treatment group were （ 1.08 ± 0. 17 ）, （ 0. 76 ± 0. 89 ） μg·L^-1, alanine aminotransferase were （ 50. 82 ±5.59 ）, （ 34. 97 ±4.03 ） U·L^-1, aspartate aminotransferase were （54.92 ± 6. 02）, （40.25 ± 4.53） U·L^-1, total bilirubin were （ 30. 11 ± 3.35 ）, （27.89 ± 3.09 ） μmol·L^-1, direct bilirubin were （ 18.02 ± 2.01 ）, （ 13.60 ± 1.67 ） μmol·L^-1, albumin were （35.92±4. 45 ）, （42. 03 ± 4. 70 ） g·L^-1, the difference had statistically significant （ P 〈 0. 05 ）. The adverse drug reactions in treatment group were mild gastrointestinal disorders, dizziness, headache, rash, total incidence rate of adverse reactions was 9.68% （3/31 cases）. The adverse drug reactions in control group were dizzi- ness headache, vertigo, headache, rash, cirrhosis, total incidence rate of adverse drug reaction was 22.58% （7/31 cases, P 〉 0. 05 ）. Conclusion Polyene phosphatidylcholine capsule combined with Jueming Jiangzhi tablets in the treatment of nonalcoholic fatty liver disease have a higher clinical efficacy, high sa

关 键 词：多烯磷脂酰胆碱胶囊 决明降脂片 非酒精性脂肪肝 瘦素 肝功能 

分 类 号：R972.6[医药卫生—药品]