毛囊中磺基转移酶活性与局部外用米诺地尔治疗雄激素性秃发疗效相关性研究  

The correlation study between sulfotransferase activity in hair follicles and topical minoxidil effect in the treatment of androgenetic alopecia

作　　者：雎恒春[1] 孙蔚凌[1] 范卫新[1] 

机构地区：[1]南京医科大学第一附属医院皮肤性病科,江苏南京210029

出　　处：《临床皮肤科杂志》2017年第6期395-400,共6页Journal of Clinical Dermatology

摘　　要：目的:用生物标志物预测雄激素性秃发(AGA)患者的疗效。方法:307例AGA患者在脱发边缘区拔取生长期毛发,测量磺基转移酶(SULT 1A1)活性[用吸光度(A)值表示],并询问患者年龄、脱发家族史及体重指数(BMI)。予以2%米诺地尔外用,每日2次,每次1 mL,连续治疗6个月。在基线、治疗6个月时进行全局照相评估,根据患者治疗前后脱发面积和程度的变化判断疗效,将患者分为3组,无效组为病情未控制,脱发继续加重;控制组为病情得到控制;改善组为毛发有再生。结果:治疗6个月后,每例患者测量4根毛发时,改善组与控制组、无效组之间A值差异有统计学意义,控制组与无效组之间A值差异无统计学意义(P_(10)=0.000,P_(1-1)=0.028,P_(0-1)=0.702);每例患者测量8根毛发时,改善组与控制组、无效组之间A值差异有统计学意义,控制组与无效组之间A值差异无统计学意义(P_(10)=0.000,P_(1-1)=0.021,P_(0-1)=0.775)。不同疗效积分之间的A值差异无统计学意义(P>0.05)。A值与性别、年龄、脱发家族史、BMI、就诊时脱发严重程度和拔取毛发的部位无相关性。结论:检测SULT 1A1活性可以预测米诺地尔的疗效,4根毛发的敏感性为83%,特异性为82.6%;8根毛发的敏感性为83%,特异性为87%。Objective： Topical minoxidil is the most common drug used for the treatment of androgenetic alopecia（AGA） in men and women. Although topical minoxidil exhibits a good safety profile, the efficacy remains relatively low. So a biomarker for predicting patient response prior to therapy would be advantageous. Methods： Three hundred and seven AGA patients were plucked anagen hair from the border between bald and non-bald scalp, measured sulfotransferase（SULT 1A1） activity（A）, and documented age, BMI, the family history of alopeeia. All patients were given 1 mL 2% topical minoxidil solution respectively, twice a day for 6 months. Global photography was performed at baseline and 6 months in order to evaluate the drug efficacy, according to the changes of areas and degrees of hair loss before and after treatment. Results： After treatment for 6 months, A of 4 hairs were differenees in the size between the improved group and the controlled group （P=0.000）. They were differences in the size between the improved group and the ineffective group （P=0.028）. They were no differences in the size between the controlled group and the ineffective group（P〉0.05）. A of 8 hairs were differences in the size between the improved group and the controlled group（P= 0.000）. They were differences in the size between the improved group and the ineffective group（P=0.021）. They were no differences in the size between the controlled group and the ineffective group（P〉0.05）. There was no significant difference in A among the efficacy scores of 50, 100, 150. A were not affect sex, age, BMI, the family history of alopecia, the severity of alopecia during the patient＇s first visit and the part of plucked hairs. Conclusions： A of 4 hairs was able to predict responders to minoxidil therapy with a sensitivity of 83% and a specificity of 82.6%. A of 8 hairs was a sensitivity of 83% and a specificity of 87%.

关 键 词：磺基转移酶 米诺地尔 雄激素性秃发 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]