钛基表面TiO_2-HA生物陶瓷膜层的血液相容性研究  

Blood Compatibility of TiO_2-HA Bioceramic Coating on Titanium

作　　者：徐琳[1] 丁建宁[2] 许晓静[1] 何远清[1] 雷小春[1] 

机构地区：[1]江苏大学,江苏镇江212013 [2]常州大学,江苏常州213164

出　　处：《稀有金属材料与工程》2017年第5期1299-1304,共6页Rare Metal Materials and Engineering

基　　金：江苏省高校自然基金重大项目(11KJA430004);江苏省高校自然基金(12KJD460002)

摘　　要：采用微弧氧化法及微弧氧化-水热法对纯钛进行改性,制备了TiO_2与TiO_2-HA生物陶瓷膜层,通过溶血率实验、动态凝血时间实验和血小板黏附实验等方面评价其血液相容性。结果表明:各试样的溶血率都远小于5%,均符合医用材料的溶血率要求,不会产生溶血作用。与钛基TiO_2生物陶瓷膜层和钛基材相比,钛基TiO_2-HA生物陶瓷膜层的溶血率更低,动态凝血时间曲线变化更为缓慢,黏附的血小板更少,且变形程度更轻,具有更好的抑制血小板的聚集与变形的性能,血液相容性更优。Biological surface modification of titanium was conducted by micro-arc oxidation （MAO） and hydrothermal synthesis （HS） methods to prepare TiO2 bioceramic coating and TiO2-HA bioceramic coating. The blood compatibility of modified coatings was evaluated by hemolysis rate test, dynamic clotting time and platelet adhesion test. The results demonstrate that hemolysis rates of all samples are less than 5%, and no hemolysis is observed. Compared with titanium and TiO2 bioceramic coating of titanium, TiO2-HA bioceramic coating of titanium exhibits better blood compatibility, with lower hemolysis rate, longer dynamic clotting time, fewer adhered platelets and slighter formation of platelets, which could better prevent platelet shape change and aggregation.

关 键 词：纯钛 微弧氧化 水热合成 血液相容性 TiO2-HA生物陶瓷膜层 

分 类 号：R318.08[医药卫生—生物医学工程] TG174.453[医药卫生—基础医学]