血浆白细胞介素22水平与丙型肝炎患者肝功能及感染结局的相关性  

Associations of plasma IL-22 level with the liver function and infection outcomes in hepatitis C patients

作　　者：朱萍[1] 吴梦平[2] 谢超楠 田亭[2] 张云[2,3] 韩亚萍[4] 刘源[4] 金柯[4] 岳明[4] 

机构地区：[1]南京医科大学第一附属医院医务处,江苏南京210029 [2]南京医科大学公共卫生学院流行病与卫生统计学系,江苏南京210029 [3]中国人民解放军南京军区军事医学研究所,江苏南京210002 [4]南京医科大学第一附属医院感染病科,江苏南京210029

出　　处：《中华疾病控制杂志》2017年第5期501-503,518,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81502853;81273146);江苏省自然科学基金(BK20151026;BK20140094);国家重大科技专项(2013ZX10002005-002-005;2013ZX10004905)

摘　　要：目的分析江苏地区有偿献血HCV感染人群血浆白细胞介素22(interleukin-22,IL-22)水平与肝功能指标、丙型肝炎病毒(hepatitis C,HCV)载量及HCV感染结局的相关性。方法采用酶联免疫吸附法(enzyme linked immunosorbent,ELISA)检测75例HCV持续感染者、82例HCV自限清除者和90例健康对照者外周血浆中IL-22水平。分析IL-22与肝功能指标及病毒载量的相关性。结果以年龄、性别和体质指数(body mass index,BMI)为协变量,经协方差分析显示,三组间的丙氨酸氨基转移酶(alanine aminotransferase,ALT)和天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)水平差异均有统计学意义(均有P<0.05);IL-22水平在三组间的分布无统计学差异(F=0.911,P=0.676);IL-22水平与ALT、AST水平呈正相关,与HCV RNA水平呈负相关,但差异均无统计学意义(均有P>0.05)。Logistic回归分析结果显示,HCV病毒载量升高是HCV持续感染者血浆ALT水平升高的独立危险因素(OR=16.926,95%CI:1.695~169.068)。结论 HCV病毒载量与肝功能受损情况密切相关,本研究未发现血浆IL-22水平对肝功能及HCV感染结局有影响,大样本随访研究有助于进一步探讨它们之间的关系。Objective To investigate the associations of plasma interleukin-22 （IL-22） level with liver function,hepatitis C （HCV） RNA load and HCV-related outcomes among HCV infected paid blood donors of Jiangsu Province.Methods A total of 247 subjects were enrolled,including 75 HCV persistent infection cases,82 HCV natural clearance subjects and 90 healthy controls.The IL-22 level was measured by enzyme linked immunosorbent assay （ELISA）.The partial correlation analysis was used to explore the associations of IL-22 level with liver function,HCV RNA load and HCVrelated outcomes.Results After controlling for age,sex and body mass index （BMI）,the analysis of covariance showed there were significant differences in the level of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） among the three groups （all P 〈 0.05）,by contrast,no significant difference in plasma IL-22 level or the outcomes of HCV infection was observed （F =0.911,P =0.676）.In addition,a partial correlation analysis showed thatthe level of IL-22 was positively correlated with the level of ALT,AST and negatively correlated with the level of HCV RNA load.However,the correlation did not show significant differences （all P 〉 0.05）.Logistic regression implicated that HCV RNA load was an independent risk factor of ALT level in HCV persistent infection patients （OR =16.926,95% CI：1.695-169.068）.Conclusions HCV RNA load was closely related to the liver function in hepatitis C patients.In this study,no significant association was found between plasma IL-22 level and the outcomes of HCV infection.However,large well designed followup studies would be needed to further elucidate the impact of IL-22 on liver function and HCV infection outcomes.

关 键 词：丙型肝炎病毒 白细胞介素 感染 

分 类 号：R512.63[医药卫生—内科学] R181[医药卫生—临床医学]