体外受精-胚胎移植后妊娠早孕期间微量元素变化  

Serum trace elements concentrations during the first trimester of pregnancy after IVE-ET/F-ET treatment

作　　者：陈娟[1] 徐千花[1] 郭培培[1] 张勤[2] 魏兆莲[1] 曹云霞[1] 

机构地区：[1]安徽医科大学第一附属医院妇产科生殖医学中心,安徽合肥230022 [2]安徽医科大学公共卫生学院流行病与卫生统计学系,安徽合肥230032

出　　处：《中华疾病控制杂志》2017年第5期514-518,共5页Chinese Journal of Disease Control & Prevention

基　　金：卫生部公益性行业科研专项(201402004);安徽医科大学第二批"四个培育"计划项目(GJCXQT-1403)

摘　　要：目的了解接受外源性性激素治疗的体外受精-胚胎移植患者早孕期间血清微量元素水平及雌、孕激素水平的改变情况。方法收集安徽医科大学第一附属医院生殖中心接受体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)/冻融胚胎移植(frozen-thawed embryo transfer,F-ET)治疗后获妊娠者800例及自然妊娠者63例,按周期类型分为新鲜周期组(212例)、解冻人工周期组(354例)、解冻自然周期组(234例)和自然妊娠组(63例)。在妊娠后6~8周于清晨空腹测血铜、锌、钙、镁、铁五种常见微量元素值及雌二醇(estradiol,E2)、孕酮(progesterone,P)水平。结果随IVF-ET不同方案外源性激素摄入量增加,孕妇血清E2、P水平逐渐升高,自然妊娠组最低,新鲜周期组最高。四组血清铜含量间差异有统计学意义(均有P<0.05),自然妊娠组最低,解冻人工周期组最高,且铜水平与雌二醇水平呈正相关(r=0.08,P=0.024)。多胎妊娠者血清镁、铁均低于单胎妊娠者(均有P<0.05)。结论接受IVF-ET/F-ET治疗后获妊娠者早孕期间血清铜较同期自然妊娠者高,且与其血清E2水平呈正相关。多胎妊娠对镁、铁的需求较单胎妊娠高。Objective To investigate the effects of exogenous sex hormones supplementation to in vitro fertilization-embryo transfer （IVF-ET）/frozen-thawed embryo transfer （F-ET） patients on serum concentrations of five trace elements as well as estradiol （E2） and progesterone （P） in pregnant women during the first trimester of pregnancy.Methods A total of 863 pregnant women （including 800 in vitro fertilization-embryo transfer （IVF-ET）/frozen-thawed embryo transfer （F-ET） patients and 63 nature pregnancy） were studied,the IVF-ET/F-ET patients were divided into 3 groups according to their different embryo transfer cycle.Serum samples were collected in the morning of their 6-8 weeks of pregnancy and the serum concentrations of copper,zinc,calcium,magnesium,iron,estradiol and progesterone were measured.Results The serum E2 and P levels rose with the increase of hormone intake due to different IVF-ET cycles.The copper levels in four groups were significantly different （all P 〈 0.05）,the lowest in the natural pregnancy group and highest in the fresh cycle group.The copper level was positively correlated with the estradiol level （r =0.08,P =-0.024）.The levels of serum magnesium and iron in multiple pregnancies were lower than those in singleton pregnancies （all P 〈 0.05）.Conclusions Serum copper level of wegnant women who received IVF-ET / F-ET treatment is higher than that of women with natural pregnancy,and it has positive correlation with serum E2 level.The demands of magnesium and iron of multiple pregnancy are higher than those required by singleton pregnancy.

关 键 词：胚胎移植 妊娠 元素 雌二醇 孕酮 

分 类 号：R714.12[医药卫生—妇产科学] R348.5[医药卫生—临床医学]