根治手术与放疗辅助常规化疗对早期声门型喉癌局部控制率、生存率及并发症的影响  

Effect of Radical Surgery and Radiotherapy on Local Control Rate,Survival Rate and Complications in Patients with Early Stage Glottic Carcinoma

作　　者：王静[1] 李振东[1] 黄冬宁 

机构地区：[1]辽宁省肿瘤医院,110042

出　　处：《实用癌症杂志》2017年第6期1021-1023,1027,共4页The Practical Journal of Cancer

摘　　要：目的研究根治手术与放疗分别辅助常规化疗对早期声门型喉癌患者局部控制率、生存率及并发症风险的影响。方法选择早期声门型喉癌患者80例。采用随机数表法分为放疗组和手术组,每组各40例,放疗组给予放疗辅助小剂量化疗,手术组给予根治手术辅助小剂量化疗。比较两组患者的临床疗效、喉功能改善情况、并发症和复发转移情况。结果放疗组患者的生存率、无瘤生存率和局部控制率分别为95.00%、80.00%和85.00%,手术组分别为92.50%、87.50%和90.00%,差异无统计学意义(P>0.05)。放疗组喉功能完全改善和部分改善例数多于手术组,未改善例数少于手术组,差异有统计学意义(P<0.05)。手术组出现1例喉腔狭窄,2例皮下气肿,2例肺部感染和6例切口感染,放疗组出现3例吞咽困难,3例肺部感染和7例放射性皮炎/咽炎,两组患者并发症比较差异无统计学意义(P>0.05)。手术组有8例出现复发,其中原发灶复发6例,颈部淋巴结转移2例,放疗组患者有9例出现复发,其中其中原发灶复发7例,颈部淋巴结转移2例,两组患者的复发转移情况比较差异无统计学意义(P>0.05)。结论根治手术与放疗分别辅助常规化疗对早期声门型喉癌患者的疗效相近,效果较好,并发症和复发转移情况类似,放疗辅助常规化疗对喉功能的影响较小,患者生活质量较高。Objective To study the effect of radical surgery and radiotherapy on local control rate, survival rate and com- plications in patients with early stage glottic carcinoma. Methods 80 cases of patients with early stage glottic carcinoma were se- lected. They were divided into the radiotherapy group and the operation group, each group had 40 cases. The radiotherapy group was treated with radiotherapy combined with small dose chemotherapy, and the operation group was treated with operation com- bined with small dose chemotherapy. Compared the clinical efficacy, improvement of laryngeal function, complications and recur- rence and metastasis between the 2 groups. Results Survival and disease-free survival and local control rates of the radiotherapy group were 95.00% ,80.00% and 85.00% , and of the operation group were 92.50% ,87.50% and 90.00% , the difference had no statistical significance （P 〉 0.05 ）. Patients with laryngeal function completely improved and partial response in the radiothera- py group were more than the operation group, none response cases was less than the operation group, the difference had statistical significance （ P 〈 0.05 ）. In the surgery group, there had 1 case of laryngeal cavity stenosis,2 cases of subcutaneous emphysema,2 cases of pulmonary infection and 6 cases of incision infection, in the radiotherapy group, there had 3 cases of dysphagia,3 cases of pulmonary infection and 7 cases of radioactive dermatitis/pharyngitis, the difference in complications between the 2 groups had no statistical significance （ P 〉 0.05 ）. In the surgery group, there had 8 cases of recurrence, 6 cases of primary tumor recurrence, cer- vical lymph node metastasis in 2 cases, in the radiotherapy group, there had 9 cases of recurrence ,7 cases of primary tumor recur- rence ,2 cases of neck lymph node metastasis, the difference in recurrence and metastasis between the 2 groups had no statistical significance（ P 〉 0. 05 ）. Conclusion Surgery and radiotherapy as adjuvant treatment to conven

关 键 词：手术 放疗 化疗 早期声门型喉癌 

分 类 号：R739.65[医药卫生—肿瘤]