液固压缩技术速释复方丹参片中丹参酮ⅡA的研究  

Investigaion of Improving Dissolution Rate of Tanshinone ⅡA in Fufang Danshen Tablets by Liquisolid Compacts Technique

作　　者：孙丹丹[1] 闫雪生[1] 于蓓蓓[1] 徐新刚[1] 

机构地区：[1]山东省中医药研究院,山东济南250014

出　　处：《辽宁中医杂志》2017年第5期1022-1025,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：山东省自然基金(ZR2015PH015)

摘　　要：目的:探讨液固压缩技术提高复方丹参片中丹参酮ⅡA溶出度的机制。方法:制备药液比为1:2,PEG400为液体载体,硅酸铝镁为载体材料和涂层材料的复方丹参液固压缩片,将其溶出度与市售的复方丹参片进行比较,并通过X-衍射和差示扫描量热分析考察丹参酮ⅡA的存在状态变化。结果:液固压缩片中丹参酮ⅡA的溶出度较市售片大幅度提高,X-衍射和差示扫描量热分析表明液固压缩片中丹参酮ⅡA的特征峰消失。结论:液固压缩技术可以改善丹参酮ⅡA的溶出度,快速释药。Objective ： To investigate the mechanism of improving dissolution rate of tanshinone Ⅱ A in Fufang Danshen Tablets by liquisolid compacts technique. Methods：The Fufang Danshen Liquid- solid compressed tablets were prepared with solid -liquid ratio of 1：2, PEG400 as liquid vehicle, magnesium aluminum silicate as carrier and coating materials. Dissolution rate of liqu- isolid tablets and common tablets were compared. The tanshinone Ⅱ A was characterized by differential scanning calorimetry （DSC） and X- Ray diffraction. Results：Fufang Danshen liquidsolid compressed tablets were much more soluble than common tablets. DSC and X - Ray diffraction showed that the characteristic peaks of drug in liquisolid tablets had vanished. Conclusion ： Liquisolid compacts can increase dissolution of tanshinone Ⅱ A in Fufang Danshen Tablets.

关 键 词：液固压缩技术 丹参酮ⅡA 溶出度 X-衍射 差示扫描量热分析 

分 类 号：R284[医药卫生—中药学]