复方竹叶石膏颗粒、沙参麦冬汤、血府逐瘀汤防治家兔急性放射性食管炎的比较研究  

Effect Observation of Compound Zhuye Shigao Granule,Shashen Maidong Decoction and Xuefu Zhuyu Decoction in Prevention of Rabbits with Radioactive Esophagitis

作　　者：李明伟[1] 路军章[1] 王丽娟[1] 陈格格 牛保龙[2] 曲宝林[2] 朱凤伟[3] 

机构地区：[1]解放军总医院中医科,北京100853 [2]解放军总医院放疗科,北京100853 [3]解放军总医院病理科,北京100853

出　　处：《解放军医药杂志》2017年第5期9-13,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：国家自然基金课题资助项目(81373543)

摘　　要：目的观察复方竹叶石膏颗粒与沙参麦冬汤、血府逐瘀汤防治家兔急性放射性食管炎的效果。方法将50只家兔随机分为对照组、模型组、沙参麦冬汤组、血府逐瘀汤组、复方竹叶石膏颗粒组,每组10只,除对照组外其余各组均制备放射性食管炎模型,给药组于X线照射前1周给药至照射后7 d。照射后7 d取各组家兔食管组织,观察食管病理损伤程度并评分,并检测一氧化氮(NO)、抑制羟自由基能力及过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-PX)的浓度。结果模型组及各给药组食管组织病理损伤评分均高于对照组,复方竹叶石膏颗粒组低于沙参麦冬汤组和血府逐瘀汤组(P<0.05);模型组及各给药组NO、CAT和GSH-PX浓度均高于对照组,抑制羟自由基能力低于对照组(P<0.05);复方竹叶石膏颗粒组NO、CAT和GSH-PX浓度低于沙参麦冬汤组和血府逐瘀汤组,抑制羟自由基能力高于沙参麦冬汤组和血府逐瘀汤组(P<0.05)。结论复方竹叶石膏颗粒能显著减轻放射性食管炎食管组织病理损伤、抑制氧自由基水平。Objective To observe effects Compound Zhuye Shigao Granule （CZSG）, Shashen Maidong Decoction （SSMD） and Xuefu Zhuyu Decoction （XFZY） in prevention of rabbits with radiation esophagitis. Methods A total of 50 rabbits, were randomly divided into control group, model group, SSMD group, XFZY group and CZSG group （n = 10 for each group）. All rabbits except those in control group were established radioactive esophagitis rabbit models. In medication groups, drugs were given starting from I week before radiation to at 7th d after radiation. In all groups, oesophageal tissues were collected at 7th d after radiation, and scores of pathological changes were also observed, and then contents of nitric oxide （ NO）, capacity of inhibiting hydroxyl radical （ OH）, catalase （CAT） and glutathione peroxidase （GSH-PX） were detected. Results Pathological scores in model group and medication groups were significantly higher than those in control group, and the score in CZSG group was significantly lower than that in SSMD and XFZY groups （P 〈0. 05）. Contents of NO, CAT and GSH-PX in model group and medication groups were significantly higher, while capacity of inhibiting OH was significantly decreased compared with those in control group （P 〈0. 05） ; contents of NO, CAT and GSH-PX in CZSG group were significantly lower than those in SSMD and XFZY groups, while capacity of inhibiting OH was significantly increased compared with those in SSMD and XFZY groups （ P 〈 0.05 ）. Conclusion Compound Zhuye Shigao Granule （CZSG） can significantly decrease pathological damage of oesophageal tissues of esophagitis and inhibit oxygen radical level.

关 键 词：食管炎 放射性 复方竹叶石膏颗粒 自由基 兔 

分 类 号：R332[医药卫生—人体生理学] R818.85[医药卫生—基础医学]