阻塞性睡眠呼吸暂停综合征与2型糖尿病及C反应蛋白的关系  

Relationship between obstructive sleep apnea syndrome with type 2 diabetes mellitus and C-reactive protein

作　　者：帖永新[1] 付月云[1] 徐震[1] 彭燕[1] 

机构地区：[1]新乡市中心医院,河南新乡453000

出　　处：《包头医学院学报》2017年第5期1-2,5,共3页Journal of Baotou Medical College

基　　金：新乡市重点科技攻关计划项目(ZG12020)

摘　　要：目的:探讨阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)综合征与2型糖尿病及C反应蛋白的关系。方法:经多导睡眠图监测确诊的OSA患者60例,其中30例合并2型糖尿病,为OSA合并糖尿病组,其余30例患者无糖尿病,为OSA组,20例经多导睡眠图监测正常者为对照组,分别测定C反应蛋白(C-reactive protein,CRP)水平。结果:与对照组比较,OSA组、OSA合并糖尿病组CRP水平均增高(P<0.01),OSA合并糖尿病组与OSA组比较,OSA合并糖尿病组CRP增高(P<0.05)。结论:OSA组及OSA合并糖尿病组CRP水平较对照组均有增高,OSA合并糖尿病患者较单纯OSA患者CRP水平增高,因此炎性指标CRP可作为OSA患者及OSA患者发生糖尿病风险的临床检测指标。Objective： To discuss the relationship between obstructive sleep apnea（ OSA） syndrome with type 2 diabetes mellitus and C-reactive protein（ CRP）.Methods： 60 cases confirmed with OSA by polysomnography（ PSG） were divided into OSA complicated with diabetes mellitus group（ 30 cases） and OSA group（ 30cases）. 20 cases with normal polysomnography were selected as control group. CRP levels were measured in each group. Results： CRP levels in OSA group and OSA complicated with diabetes mellitus group were higher than that in control group（ P〈0. 01）. CRP level in OSA complicated with diabetes mellitus group was higher than that in OSA group（ P〈0. 05）. Conclusion： CRP levels in OSA group and OSA complicated with diabetes mellitus group are higher than that in control group and CRP level in OSA complicated with diabetes mellitus group is higher than that in OSA group. So CRP,the inflammatory indicator,can be used as an index of clinical detection of diabetes risk in patients with OSA.

关 键 词：C反应蛋白 阻塞性睡眠呼吸暂停 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R766[医药卫生—内科学]