原发性高血压患者血浆同型半胱氨酸水平与24小时血压变异性的关系  

Relevance between plasma homocysteine level and 24 h blood pressure variability in patients with essential hypertension

作　　者：周绮[1] 余振球[1] 吉庆伟[2] 

机构地区：[1]首都医科大学附属北京安贞医院高血压科,100029 [2]首都医科大学附属北京安贞医院急诊危重症中心,100029

出　　处：《中国医药》2017年第6期827-830,共4页China Medicine

基　　金：国家自然科学基金（81160045）

摘　　要：目的探讨原发性高血压（EH）患者血浆同型半胱氨酸（Hcy）与24h血压变异性（BPV）之间的关系。方法随机选取2015年10月至2016年11月在首都医科大学附属北京安贞医院高血压科住院的EH患者344例，所有患者均行24h动态血压监测，计算24h收缩压变异系数和24h舒张压变异系数，并测定血浆Hcy、血脂、血糖水平。根据血浆Hcy水平将患者分为3组：A组160例（Hcy〈15．0μmol／L），B组94例（15．0μmoL／L≤Hcy〈20．0μmol／L），C组90例（Hcy／〉20．0μmol／L）。分析BPV（24h收缩压及舒张压变异系数）与Hcy之间的关系。结果3组血脂、血糖水平比较差异均无统计学意义（均P〉0．05）。B组和C组24h收缩压变异系数和24h舒张压变异系数均明显高于A组[（10．7±2．5）、（10．8±3．4）比（9．4±2．3），（10．9±2．7）、（11．4±2．2）比（10．2±2．0）]，差异均有统计学意义（均P〈0．05）；B组和C组间24h收缩压及舒张压变异系数差异无统计学意义（P〉0．05）。Spearman相关性分析显示，24h收缩压变异系数与Hcy之间的相关系数为0．132（P〈0．05），24h舒张压变异系数与Hcy之间相关系数为0．154（P〈0．05）。结论EH患者血浆Hcy水平升高与BPV增加有关，合并高Hcy血症可能是BPV增加的危险因素。Objective To investigate the relevance between level of plasma homocysteine （Hcy） and 24 h blood pressure variability（BPV） in patients with essential hypertension（EH）. Methods Totally 344 EH patients from October 2015 to November 2016 in Beijing Anzhen Hospital, Capital Medical University had 24 h ambulatory blood pressure monitoring to measure systolic and diastolic pressure variation coefficients; levels of plasma Hey, blood lipid and glucose were tested. The patients were divided into 3 groups according to the level of Hcy; group A had 160 cases （Hcy 〈 15.0 μ mol/L） , group B had 94 cases （15.0 μmol/L ≤ Hcy 〈 20.0 p, mol/L） and group C had 90 eases（ Hcy≥20.0 μmol/L）. The correlation between BPV（24 h systolic and diastolic pressure variation coefficients） and Hcy was analyzed. Results Levels of blood lipid and glucose had no significant differences between groups （ P 〉 0. 05 ）. The 24 h systolic pressure variation coefficient and 24 h diastolic pressure variation coefficient in group B, C were significantly higher than those in group A [（10.7 ±2.5）,（10.8 ±3.4） vs （9.4±2.3）;（10.9±2.7）,（11.4±2.2） vs （10.2±2.0）]（P〈0.05）; there were no significant differences between group B and group C （ P 〉 0. 05 ）. Spearman analysis showed a correlation between BPV and Hey; the coefficient of correlation between 24 h systolic pressure variation coefficient and Hcy level was 0. 132 （P 〈 0. 05 ） ; the coefficient of correlation between 24 h diastolic pressure variation coefficient and Hey level was 0. 154 （ P 〈 0.05 ）. Conclusion There is a correlation between Hey and BPV in patients with EH.

关 键 词：原发性高血压 同型半胱氨酸 血压变异性 

分 类 号：R544.1[医药卫生—心血管疾病]