Antimicrobial Susceptibility Testing and Molecular Characterization of Mycobacterium fortuitum Isolates in China  

作　　者：ZHENG Hui Wen PANG Yu HE Guang Xue SONG Yuan Yuan ZHAO Yan Lin 

机构地区：[1]National institute for communicable disease control and prevention, Chinese center for disease control and prevention, Beijing 102206, China [2]National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing 102206, China [3]Science and Technology Department, Chinese Center for Disease Control and Prevention, Beijing 102206, China

出　　处：《Biomedical and Environmental Sciences》2017年第5期376-379,共4页生物医学与环境科学（英文版）

基　　金：supported by a grant from the National Basic Research Program of China 2014CB744403;National Science and Technology Major Project 2014ZX100030002

摘　　要：We performed molecular identification of clinical isolates of Mycobacterium fortuitum（M. fortuitum） and conducted drug susceptibility testing to analyze the in vitro susceptibility of clinical M. fortuitum isolates and potential molecular mechanism conferring resistance to fluoroquinolone and macrolide drugs. The results showed that moxifloxacin had the highest in vitro activity against M. fortuitum, and most M. fortuitum isolates were resistant to clarithromycin and linezolid in China. The loss of genetic mutation in clarithromycin-and amikacin-resistant isolates indicates that some other intrinsic mechanism conferring clarithromycin and amikacin resistance plays an essential role in M. fortuitum infection.We performed molecular identification of clinical isolates of Mycobacterium fortuitum（M. fortuitum） and conducted drug susceptibility testing to analyze the in vitro susceptibility of clinical M. fortuitum isolates and potential molecular mechanism conferring resistance to fluoroquinolone and macrolide drugs. The results showed that moxifloxacin had the highest in vitro activity against M. fortuitum, and most M. fortuitum isolates were resistant to clarithromycin and linezolid in China. The loss of genetic mutation in clarithromycin-and amikacin-resistant isolates indicates that some other intrinsic mechanism conferring clarithromycin and amikacin resistance plays an essential role in M. fortuitum infection.

关 键 词：Nontuberculosis Genotype Phenotype Susceptibility 

分 类 号：R446.5[医药卫生—诊断学]