早孕期胎儿中枢神经系统畸形的超声影像诊断  

Prenatal ultrasonographic diagnosis of fetal central nervous system abnormalities during the first trimester

作　　者：华方明 任苓[1] 曾庆新[1] 程玲[1] 吴牡丹[1] 叶军[1] 

机构地区：[1]赣南医学院第一附属医院超声诊断科,江西赣州341000

出　　处：《中华超声影像学杂志》2017年第5期410-413,共4页Chinese Journal of Ultrasonography

摘　　要：目的探讨超声检查对早孕期胎儿中枢神经系统（CNS）的显示情况及其对早孕期胎儿CNS畸形的诊断价值。方法2751例入组的研究对象根据超声测量头臀长（CRL）后估测的孕周分为：孕11～11＋6周组、孕12～12＋6周组和孕13～13＋6周组，应用超声影像对早孕期胎儿CNS解剖结构进行检查，统计并分析各组胎儿CNS解剖结构的显示情况及其与孕周的关系，计算早孕期超声影像诊断胎儿CNS畸形的敏感度。结果本组中共诊断胎儿CNS畸形14例20处畸形，CNS畸形的发生率为5．09‰。其中早孕期诊断12例，中孕期诊断2例，早孕期超声影像诊断胎儿CNS畸形的敏感度为85．71％。孕11～11＋6周、孕12～12＋6周、孕13～13＋6周胎儿CNS解剖结构显示率分别为96．73％、97．94％、98，06％，不同孕组间胎儿CNS结构显示率的差异无统计学意义（χ2=1．56，v=2，χ2〈0.05,2=5．99，P〉0．05）。结论早孕期（11～13＋6周）胎儿CNS结构的显示率较高，且不受孕周的影响；超声检查可以有效地诊断出早孕期胎儿CNS严重畸形。Objective To investigate the display status of uhrasonography imaging check in central nervous system （CNS） in infants of early pregnancy and the diagnostic value of CNS malformation in infants of early pregnancy. Methods Gestational weeks of 2 751 enrolled subjects were divided according to the ultrasonic measurement of the crown rump length （CRL）：11 - 11 ＋6 weeks group, 12 - 12＋6 weeks group, and 13 - 13 ＋6 weeks group, prenatal ultrasound were performed to examine fetal CNS anatomy in infants of early pregnancy, record the display status in each groups of infants and analyze the relationship between the display situation and gestational age. Results Fourteen cases of fetal CNS malformation （20 malformations） in total were found by prenatal ultrasound, and the incidence of CNS malformation was about 5.09%0 （14/2 571 ）. Wherein, 12 cases of early pregnancy were diagnosed, and 2 cases of middle pregnancy were diagnosed. The sensitivity of ultrasound of early pregnancy in the diagnosis of fetal CNS malformation was 85.71%. In the group of research, the ultrasound display ratios of 11 - 11＋6 weeks group, 12- 12＋6 weeks group and 13- 13＋%weeks group were 96.73%, 97.94%, 98.06%, respectively. There was no significant difference in early pregnancy fetal CNS display ratio among groups （χ2 = 1.56, v = 2, χ0.05,2 = 5.99, P 〉 0.05）. Conclusions The display rate of CNS structure in infants of early pregnancy （11 - 13＋6 weeks）is higher, and is not affected by gestational weeks. Prenatal ultrasound can effectively diagnose CNS severe malformation in infants of early pregnancy.

关 键 词：超声检查 产前 早孕期 中枢神经系统 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.53[医药卫生—诊断学]