戈舍瑞林对前列腺增生模型大鼠血管生长因子和免疫功能的影响  

Effects of Goserelin on Vascular Growth Factor and Immune Function of Rats with Prostatic Hyperplasia

作　　者：奚炜[1] 徐帮[2] 张永华[2] 赵倩[2] 陈进兵[2] 

机构地区：[1]三峡大学人民医院药学部,湖北宜昌443000 [2]宜昌市第一人民医院药剂科,湖北宜昌443000

出　　处：《中国药房》2017年第16期2205-2208,共4页China Pharmacy

摘　　要：目的:研究戈舍瑞林对前列腺增生模型大鼠血管生长因子及免疫功能的影响。方法:取大鼠建立前列腺增生模型,然后随机分为模型组和戈舍瑞林低、中、高剂量组(0.4、0.8、1.2 mg/kg),另取正常大鼠作为正常对照组,每组10只。正常对照组和模型组大鼠ig生理盐水,戈舍瑞林各剂量组大鼠ig相应剂量的药物,每日1次,连续25 d。检测各组大鼠前列腺体积、湿质量、前列腺指数和前列腺组织中血管内皮生长因子(VEGF)、转化生长因子β_1(TGF-β_1)、成纤维细胞生长因子(FGF)、CD4、CD8的阳性细胞面积。结果:与正常对照组比较,模型组大鼠前列腺体积、湿质量、前列腺指数和VEGF、TGF-β_1、FGF、CD4、CD8阳性细胞面积均增加(P<0.05)。与模型组比较,戈舍瑞林各剂量组大鼠上述指标均改善(P<0.05),且中、高剂量组较低剂量组改善效果更明显(P<0.05),中、高剂量组间差异无统计学意义(P>0.05)。结论:戈舍瑞林可改善大鼠的前列腺增生,减少前列腺组织中VEGF表达并调节免疫功能。OBJECTIVE： To study the effects of goserelin on vascular growth factor and immune function of rats with prostatic hyperplasia. METHODS： Rats were selected to establish prostatic hyperplasia model and randomly divided into model group, gose- relin low-dose, medium-dose and high-dose groups （0.4, 0.8, 1.2 mg/kg） ; normal rats were selected as normal control group, with 10 rats in each group. Normal control group and model group were given normal saline intragastrically, and goserelin groups were given relevant dose of drugs intragastrically, once a day, for consecutive 25 days. The prostate volume, wet weight, prostatic index of rats were detected as well as positive cell area of VEGF, TGF-β1, FGF, CD4 and CD8 in prostate tissue. RESULTS： Compared with normal control group, prostate volume, wet weight, prostatic index, positive cell area of VEGF, TGF-β1, FGF, CD4 and CD8 were all increased in model group （P〈0.05）. Compared with model group, the above indexes of goserelin groups were all improved （P〈0.05）, especially those in medium-dose and high-dose groups were better than in low-dose group （P〈 0.05）; there was no statistical significance between medium-dose group and high-dose group （P〉0.05）. CONCLUSIONS： Gosere- lin can relieve prostatic hyperplasia of rats, reduce the expression of VEGF in prostate tissue and regulate immune function.

关 键 词：前列腺增生 戈舍瑞林 大鼠 血管内皮生长因子 免疫功能 

分 类 号：R965[医药卫生—药理学]