抗血管内皮生长因子药物联合激光治疗糖尿病黄斑水肿  

Clinical effect of anti-VEGF drugs combined with laser therapy for DME patients

作　　者：殷莉[1] 张德龙[1] 任骞[1] 苏宪[1] 于华[1] 李丽[1] 孙瑞雪[1] 孙朝晖[1] 

机构地区：[1]中国河北省石家庄市第一医院眼科,050011

出　　处：《国际眼科杂志》2017年第6期1116-1118,共3页International Eye Science

基　　金：河北省卫计委支持项目(No.13010520140682)~~

摘　　要：目的:探讨抗血管内皮生长因子药物联合激光治疗糖尿病黄斑水肿(diabetic macular edema,DME)的临床效果。方法:选取2015-06/12在我院接受治疗的94例141眼DME患者,采用随机数字表法分为联合组47例68眼(雷珠单抗联合激光治疗)、对照组47例73眼(激光治疗),对比两组患者治疗后不同时间的最佳矫正视力(best corrected visual acuity,BCVA)、黄斑中心视网膜厚度(macular central retinal thickness,CRT)、黄斑总体积(total macular volume,TMV)、黄斑水肿分级。结果:治疗2、6、12wk联合组的BCVA平均值均大于对照组,差异有统计学意义(P<0.05),治疗2、6、12wk联合组的CRT、TMV平均值均小于对照组,差异有统计学意义(P<0.05);治疗12wk后,联合组黄斑水肿轻度80.9%、中度17.7%、重度1.5%,对照组轻度60.0%、中度31.5%、重度5.5%,两组比较差异有统计学意义(P<0.05)。结论:抗血管内皮生长因子药物联合激光治疗DME患者的效果优于单用激光治疗。AIM ： To investigate the endothelial growth factor laser photocoagulation （DME）. clinical effect of anti-vascular （VEGF） drugs combined with for diabetic macular edema METHODS： Totally 94 patients （141 eyes） with DME from June to December 2015 in our hospital were selected and randomly divided into combined group of 47 cases （68 eyes, ranibizumab combined with laser therapy） and the control group of 47 cases （73 eyes, laser treatment）. The levels of best corrected visual acuity （BCVA）, macular central retinal thickness （CRT）, total macular volume （TMV） and macular edema level were compared between the two groups at different time after treatment. RESULTS： The mean values of BCVA in the combined group were higher than those in the control group at 2, 6 and 12wk, and the difference was statistically significant （P〈0.05）. At 2, 6 and 12wk after treatment, the CRT and TMV values of the combined group were lower than those of the control group, the difference was statistically significant （P〈0.05）. After treated for 12wk, patients with macular edema of combined group was 80.9% in mild level, 17.7% in moderate level, 1. 5% in severe level, those of the control group was 60.0%, 31.5%, 5.5%, the difference between the two groups was statistically significant （P〈0.05）. CONCLUSION ： The effect of anti-VEGF drugs combined with laser therapy for DME patients is better than that ofsingle laser therapy alone.

关 键 词：血管内皮生长因子 激光 糖尿病黄斑水肿 

分 类 号：R587.2[医药卫生—内分泌] R774.5[医药卫生—内科学]