规范化舌下特异性免疫治疗不同年龄组儿童过敏性哮喘伴鼻炎的疗效观察  

Efficacy of standardized sublingual immunotherapy of allergic asthma with rhinitis in children between different age groups

作　　者：吴少皎[1] 陈实[1] 陈冰[1] 王灵[1] 曾霞[1] 

机构地区：[1]海南省人民医院儿科,海南海口570311

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第10期761-764,769,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：海南省社会发展科技专项(No:2015SF17)

摘　　要：目的:评估规范化舌下特异性免疫治疗(SLIT)不同年龄组儿童过敏性哮喘伴鼻炎的临床疗效。方法:回顾性分析250例3~13岁过敏性哮喘伴鼻炎患儿的临床资料,按年龄分为低龄组(3~6岁,128例)和高龄组(7~13岁,122例),进行2年SLIT治疗,评估两组患儿治疗前后的哮喘日间、夜间症状、药物评分、VAS评分和肺功能FEV1、PEF%水平以及鼻炎的症状、用药评分。结果:与治疗前相比,2组患儿在SLIT治疗半年、1年、2年时哮喘DASS、NASS、TAMS、VAS评分和肺功能FEV1、PEF%以及鼻炎的TNSS、TRMS均有显著变化,差异均有统计学意义(均P<0.05);同时,治疗在1、2年后,疗效持续得到巩固,TAMS、VAS、TNSS和TRMS进一步降低(均P<0.05);治疗后的各个时间点,仅在SLIT治疗半年时TAMS、VAS评分方面,低龄组要明显低于高龄组(Z=4.58、2.45,均P<0.05),其余组间差异无统计学意义(均P>0.05)。结论:采用标准化粉尘螨滴剂对尘螨致敏的哮喘伴鼻炎患儿进行2年SLIT能获得显著疗效,低龄组与高龄组疗效一致。Objective：The aim of this study is to evaluate the efficacy of standardized sublingual immunothera- py of allergic asthma with rhinitis in children between two different age groups. Method： Retrospective analysis of 250 patients with allergic asthma and rhinitis who received SLIT treatment. According to the age divided into younger children group（aged 3-6 years, 128 patients） and older children group（aged 7-13 years, 122 patients）. Evaluate the asthma daytime, nocturnal symptom, medication score, VAS score and pulmonary function FEV1, PEF% level and rhinitis symptom and medication score before and after treatment of two groups of children. Re- suit：The DASS, NASS, TAMS, VAS, FEV1, PEF, TNSS, TRMS had continuously improved significantly after SLIT for half a year, 1 year and 2 years in two groups as compared with baseline（P〈0.05）. The treatment after 1 year and 2 years, curative effect strengthened continuously, and TAMS, VAS, TNSS and TRMS further re duced. After treatment of each point in time, only at SLIT treatment after half a year, the TAMS, VAS score of younger children group was lower than of older children group（Z values were 4.58 and 4.58,P〈0.05）. The rest of the indicators were no statistical significance difference between the two age groups（P〉0.05）. Conclusion： Sub-lingual immunotherapy with Dermatophagoides farinae drops in younger children and older children allergic with asthma and rhinitis can play a significant and similar effect.

关 键 词：免疫疗法 投药 舌下 哮喘 变应性 鼻炎 儿童 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]