普罗布考对阻塞性睡眠呼吸暂停低通气综合征患者的影响研究  

Impact of Probucol on Patients with Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：张利[1] 董晓柳[2] 张秀清[2] 关菲[1] 辛佳[3] 徐士军[2] 李丽[4] 

机构地区：[1]河北省唐山市人民医院神经外科,063000 [2]河北省唐山市人民医院神经内科,063000 [3]河北省唐山市人民医院急诊科,063000 [4]开滦总医院林西医院检验科,河北省唐山市063000

出　　处：《实用心脑肺血管病杂志》2017年第4期43-47,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：河北省医学科学研究重点课题(20171287)

摘　　要：目的探讨普罗布考对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的影响。方法选取2013年12月—2014年12月唐山市人民医院收治的OSAHS患者88例,采用随机数字表法分为对照组和观察组,每组44例。对照组患者给予阿托伐他汀钙片治疗,观察组患者给予普罗布考治疗;两组患者均连续治疗12个月。比较两组患者治疗前后血脂指标[包括总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、空腹血糖、空腹胰岛素、胰岛素抵抗指数(HOMA-IR)、睡眠呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSaO_2)及血清抵抗素、脂联素水平,AHI与OSAHS患者其他观察指标间的相关性分析采用Pearson相关性分析。结果两组患者治疗前TC、TG、LDL-C、HDL-C比较,差异无统计学意义(P>0.05);治疗后观察组患者TC、TG、LDL-C低于对照组,HDL-C高于对照组(P<0.05)。两组患者治疗后TC、TG、LDL-C低于治疗前,HDL-C高于治疗前(P<0.05)。两组患者治疗前空腹血糖、空腹胰岛素、HOMA-IR及治疗后空腹血糖比较,差异无统计学意义(P>0.05);治疗后观察组患者空腹胰岛素、HOMA-IR低于对照组(P<0.05)。两组患者治疗后空腹胰岛素、HOMA-IR低于治疗前(P<0.05)。两组患者治疗前AHI、LSaO_2比较,差异无统计学意义(P>0.05);治疗后观察组患者AHI低于对照组,LSaO_2高于对照组(P<0.05)。两组患者治疗后AHI低于治疗前,LSaO_2高于治疗前(P<0.05)。两组患者治疗前血清抵抗素、脂联素水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清抵抗素水平低于对照组,血清脂联素水平高于对照组(P<0.05)。两组患者治疗后血清抵抗素水平低于治疗前,血清脂联素水平高于治疗前(P<0.05)。Pearson相关性分析结果显示,AHI与OSAHS患者TC、TG、LDL-C、空腹胰岛素、HOMA-IR及血清抵抗素水平呈正相关(r值分别为0.536、0.392、0.497、0.386、0.401、0.512,PObjective To investigate theimpact of probueol on patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods A total of 88 patient with OSAHS were selected in the People＇s Hospital of Tangshan from December 2013 to December 2014, and they were divided into control group and observation group according to random number table, each of 44 cases. Patients of control group received atorvastatin calcium tablets, while patients of observation group received probucol; both groups continuously treated for 12 months. Blood lipids index （including TC, TG, LDL-C and HDL- C）, FPG, FINS, HOMA-IR, AHI, LSaO2, serum levels of resistin and adiponectin were compared between the two groups before and after treatment, meanwhile Pearson correlation analysis was used to analyze the correlations of AHI with other observation index. Results No statistically significant differences of TC, TG, LDL-C or HDL-C was found between the two groups before treatment （P 〉 0. 05 ） ; after treatment, TC, TG and LDL-C of observation group were statistically significantly lower than those of control group, while HDL-C of observation group was statistically significantly higher than that of control group （P 〈 0.05）. After treatment, TC, TG and LDL-C of the two groups were statistically significantly lower than those before treatment, while HDL-C of the two groups was statistically significantly higher than that before treatment, respectively （P 〈 0. 05）. No statistically significant differences of FPG, FINS or HOMA-IR was found between the two groups before treatment, nor was FPG between the two groups after treatment （P 〉 O. 05 ）, while FINS and HOMA-IR of observation group were statistically significantly lower than those of control group after treatment （ P 〈 O. 05 ）. After treatment, FINS and HOMA-IR of the two groups were statistically significantly lower than those before treatment （P 〈0. 05）. No statistically significant differences of AHI or LSaO2 was found between the two groups before

关 键 词：睡眠呼吸暂停 阻塞性 普罗布考 抵抗素 脂联素 

分 类 号：R563.8[医药卫生—呼吸系统]