磁共振弥散张量成像技术评价高血压对年轻成年人脑白质损伤  

Evaluation of the effects of high blood pressure on white matter lesion in young adults using diffusion tensor imaging

作　　者：张华[1] 庄霞 刘振东[1] 刁玉涛[1] 杜佳晨 崔谊[3] 

机构地区：[1]山东省医学科学院基础医学研究所,山东济南250062 [2]德州市卫生与计划生育委员会,山东德州253000 [3]山东大学齐鲁医院放射科,山东济南250012

出　　处：《山东大学学报（医学版）》2017年第5期56-60,65,共6页Journal of Shandong University:Health Sciences

基　　金：山东省科技发展计划项目(2014GSF118102);山东省自然科学基金(ZR2016HM82);山东省医药卫生科技发展计划项目(2014WS0039);山东省卫生和计划生育科研项目[(2014)年第(15)号]

摘　　要：目的探讨50岁以下成年高血压患者脑白质微细结构损伤。方法应用磁共振(MRI)弥散张量成像(DTI)技术对45例高血压患者(高血压组)及45例年龄性别相匹配的对照组分别行常规MRI及DTI检查,测量其半卵圆中心、大脑脚、放射冠、胼胝体膝部、压部、体部、内囊前、后肢、额叶、顶叶、颞叶及枕叶脑白质部分各向异性分数(FA)。结果高血压组患者双侧大脑脚及额叶的FA值均低于对照组,差异均有统计学意义(P<0.001)。高血压组大脑脚左右两侧FA值与收缩压呈负相关(r=-0.625,r=-0.665,P<0.001),额叶的左右两侧FA值亦与收缩压呈负相关(r=-0.417,r=-0.495,P<0.05),与舒张压无相关关系;高血压组其他脑区白质FA值与收缩压及舒张压均无相关关系(P>0.05)。结论 50岁以下成年高血压患者中已经存在脑白质细微结构损伤,提示应尽早对该人群的血压进行合理控制。Objective To explore subtle white matter lesions in young hypertensive adults using magnetic resonance diffusion tensor imaging （DTI）. Methods Routine brain MRI and DTI sequences were performed in participants with hypertension （n = 45, hypertension group） and controls with normal blood pressure （n = 45, control group）. Fractional anisotropy （FA） values of centrum ovale, cerebral peduncle, corona radiata, genu of corpus callosum, splenium of corpus callosum, corpus callosum body, anterior limb of internal capsule, posterior limb of internal capsule, bilateral frontal lobe, parietal lobe, temporal lobe and occipital lobe were measured. Results Compared with the control group, the hypertension group had significantly decreased FA values in the cerebral peduncle and frontal lobe （P 〈 0. 001 ）. FA values in the cerebral peduncle and frontal lobe were negatively correlated with systolic blood pressure （ r = - 0. 625, r = - 0. 665, P 〈 0. 001 ; r = - 0. 417, r = - 0. 495, P 〈 0.05 ）. FA values of the other regions of the white matter were not correlated with either systolic pressure or diastolic pressure （ P 〉 0.05 ）. Conclusion The microstruc- tural white matter in young adults with hypertension may be selectively impaired, indicating the need for early and opti- mum control of blood pressure.

关 键 词：弥散张量成像 年轻成年人 脑白质损伤 高血压 

分 类 号：R814.42[医药卫生—影像医学与核医学]