CAG、IMT、hs-CRP、血脂在冠心病严重程度评估中的临床意义  

The clinical significance of CAG,IMT,hs-CRP and lipid to evaluate the severity of coronary heart disease

作　　者：石运生[1] 张利民[1] 董茂盛[1] 李妍辰[1] 贾关亮 张波[1] 常美丽[1] 

机构地区：[1]内蒙古包头市第八医院心内科,内蒙古包头014040

出　　处：《临床医药文献电子杂志》2017年第18期3372-3374,共3页Electronic Journal of Clinical Medical Literature

摘　　要：目的观察经冠脉造影证实的不稳定心绞痛(UAP)患者,检测颈动脉内中膜厚度(IMT),高敏C反应蛋白(hs-CRP)、血脂,并与冠状动脉造影(CAG)结果进行分析,从多角度探讨IMT、hsCRP、血脂与冠心病严重程度的相关性。方法随机入选冠心病患者151例,分为UAP组和稳定性心绞痛(SAP)组。两组患者均进行冠脉造影检查,对冠脉病变的部位、程度进行比较分析;超声检测IMT,检测血清hs-CRP、血脂水平,两组指标对比分析。结果两组比较,hs-CRP、TG、IMT、Gensini评分UAP组均高于SAP组,HDL-C组间比较UAP组低于SAP组,P<0.05,差异有统计学意义。UAP组颈动脉斑块发生率均高于SAP组,冠脉造影中重度狭窄发生率高于SAP组;双支及三支病变发生率高于SAP组,P<0.05,差异有统计学意义。多因素线性回归分析结果显示,hs-CRP、TG、IMT与冠脉Gensini评分呈正相关,P<0.05;其余指标与Gensini评分无相关(P>0.05)。结论不稳定心绞痛hs-CRP、TG、IMT、Gensini评分、颈动脉斑块发生率、冠脉造影中重度狭窄发生率均增高;冠脉病变严重程度与hs-CRP、TG、IMT呈正相关。Objective Among the patients with unstable angina pectoris confirmed by coronary angiography, detecting their carotid intima-media thickness （IMT）,high sensitive C reactive protein （hs-CRP） and lipid which compared with the results of coronary angiography （CAG）,to discuss the relativity between IMT, hs-CRP, lipid and the severity of coronary heart disease. Methods 151 patients were randomly selected in our research divided into unstable angina pectoris group （UAP） and stable angina pectoris group （SAP）.All patients were performed coronary angiography to compare the location and the degree of coronary lesions; IMT was detected by ultrasonic,and the serum hs-CRP and blood lipid were detected. Results Hs-CRP, TG,IMT, Gensini score of UAP group were higher than that of SAP group,while HDL-C pointed to the opposite conclusion,the differences were statistically significant （P〈0.05）.The incidence of carotid plaque,severe stenosis and double or three lesions in the UAP group were higher compared with the SAP group,the difference was statistically significant （P〈0.05）.Multivariate linear regression analysis showed that hs-CRP, TG,IMT were positively correlated with Gensini score （P〈0.05）.yet the other indexes had nothing to do with Gensini score （P〉0.05）. Conclusion Hs-CRP, TG,IMT, Gensini score,incidence of carotid plaque and severe stenosis were increased in the patients of unstable angina pectoris; the severity of coronary artery lesion was positively correlated with hs-CRP, TG and IMT.

关 键 词：冠状动脉造影 颈动脉内中膜厚度 HS-CRP 血脂 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]