钙结合蛋白-D28K在神经退行性疾病中的作用  

Role of calbindin-D28K in neurodegenerative diseases

作　　者：何莲子[1] 邓媛媛[1] 高健美[2] 龚其海[1] 

机构地区：[1]遵义医学院基础药理教育部重点实验室暨特色民族药教育部国际合作联合实验室,贵州遵义563099 [2]遵义医学院药学院,贵州遵义563099

出　　处：《中国新药与临床杂志》2017年第5期254-258,共5页Chinese Journal of New Drugs and Clinical Remedies

基　　金：贵州省高层次创新人才"百"层次(黔科合平台人才20165684号);遵义医学院优秀青年人才计划(15zy-002)

摘　　要：维生素D依赖型钙结合蛋白-D28K(calbindin-D28K)是一种具有较高钙离子亲和力的钙调蛋白,可调节胞内钙离子浓度,通过上调calbindin-D28K在神经细胞中的表达对神经退行性疾病有积极作用。本文综述了国内外calbindin-D28K在阿尔采末病、帕金森病、亨廷顿病等神经退行性疾病中相关作用的研究进展,旨在为研究以calbindin-D28K为靶点治疗神经退行性疾病提供线索。Vitamin D- dependent calbindin- D28K is a calmodulin with high calcium affinity, which regulates the concentration of intracellular calcium. Upregulation of calbindin- D28K plays a positive role in neurodegenerative diseases. Based on the research of calbindin- D28K at home and abroad, this review systematically summarizes the recent research of calbindin- D28K in neurodegenerative diseases such as Alzheimer＇ s disease, Parkinson＇ s disease, Huntington＇ s disease, and their related mechanisms. It will provide clues for the study of calbindin-D28K as a target for treating neurodegenerative diseases.

关 键 词：神经变性疾病 钙结合蛋白 维生素D依赖性 阿尔茨海默病 帕金森病 

分 类 号：R971[医药卫生—药品]