感音神经性耳聋的基因治疗研究进展  

Developments in Gene Therapy for Sensorineural Hearing Loss

作　　者：吴皓[1,2,3] 孙常领[1,2,3] 

机构地区：[1]上海交通大学医学院附属第九人民医院,上海200011 [2]上海交通大学医学院耳科学研究所,上海200011 [3]上海市耳鼻疾病转化医学重点实验室,上海200011

出　　处：《中国听力语言康复科学杂志》2017年第3期201-204,共4页Chinese Scientific Journal of Hearing and Speech Rehabilitation

基　　金：上海市科委基础重大项目(14DJ1400200);国家自然科学基金重点项目(81330023)

摘　　要：耳聋是最为常见的一种感觉障碍性疾病。目前,感音神经性耳聋尚缺乏理想的治疗方法。近年来,基因治疗在听神经和毛细胞的保护与再生、遗传性耳聋的治疗等领域显示出了极大的潜力,有望成为解决感音神经性耳聋这一难题的有效方法。本文从感音神经性耳聋基因治疗的主要策略、基因治疗载体及基因载体导入途径等方面对感音神经性耳聋的基因治疗进行综述。Hearing loss is one of the most prevalent sensory disabilities in the world, and no effective treatment is available currently. Recently, the gene therapy has become more promising in terms of protection or regeneration of the auditory nerves and hair cells, and treatment of hereditary hearing loss. The gene therapy is now being explored as a possible treatment for sensorineural hearing loss. Main strategies of treatment, gene transfer vectors and routes of delivery will be discussed in this review.

关 键 词：基因治疗 耳聋 基因载体 

分 类 号：R450[医药卫生—治疗学] R764.43[医药卫生—临床医学]