中医治疗缓慢性心律失常的临床组方规律分析  

Analysis of Clinical Prescription Rule of Bradyarrhythmias Treated by Traditional Chinese Medicine

作　　者：殷胜骏[1] 韩涛[2] 张刚[1] 刘炜[1] 

机构地区：[1]天津医科大学第二医院,天津300211 [2]北京中医药大学日本分校

出　　处：《中国实验方剂学杂志》2017年第11期220-224,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:借助数据挖掘手段,探讨中医药治疗缓慢性心律失常临床研究的组方规律。方法:检索CNKI数据库1975—2015年中医药治疗缓慢性心律失常的临床研究文献,采用频数分析、剂量分析和关联规则探索常用有效中药、药对及剂量。结果:对筛选出的56张处方中102味中药进行分析,确定处方中药物的使用频次和药物之间的关联规则,挖掘出6味核心中药和2个核心药对(桂枝+附子、附子+细辛+麻黄),并确定其参考剂量为黄芪15~50 g,附子6~20.5 g,丹参12~30 g,桂枝9~20 g,麻黄5~10 g,细辛3~10 g。结论:中医药治疗缓慢性心律失常的核心药物为黄芪、附子、丹参、桂枝、麻黄、细辛,黄芪宜为君药。Objective： To analyze the prescription rule of traditional Chinese medicine （TCM） medication for bradyarrhythmias by means of data mining. Method： The clinical research literature on TCM for bradyarrhythmias from 1975 to 2015 was searched in CNKI, a database of TCM decoctions for bradyarrhythmias was established. The frequency, dosage and association rule of the herbs were analyzed. Result： Based on the analysis of 102 herbs in 56 prescriptions, the frequency and dosage of each herb and association rules among the herbs were computed, 6 main herbs and 2 core combinations were mined from the database. Conclusion： The core herbs of TCM for bradyarrhythmias are Aconiti Lateralis Radix Praeparata, Cinnamomi Ramulus, Astragali Radix and so on, Astragali Radix should be as a monarch herb in prescription.

关 键 词：缓慢性心律失常 中医药 组方规律 数据挖掘 黄芪 附子 

分 类 号：R259[医药卫生—中西医结合] R287[医药卫生—中医内科学]