椎体成形骨填充材料的研究与现状  

Research progress of bone filling materials in percutaneous vertebroplasty

作　　者：孙育良 熊小明[2] 何本祥[1] 吴骁[1] 咸杰[1] 

机构地区：[1]成都体育学院,四川省成都市610041 [2]四川省骨科医院,四川省成都市610041

出　　处：《中国组织工程研究》2017年第14期2285-2290,共6页Chinese Journal of Tissue Engineering Research

基　　金：四川省科技厅支撑计划(2015SZ0190);国家科技支撑计划(2012BAK21B01-02)~~

摘　　要：背景:椎体成形是治疗骨质疏松性椎体压缩骨折安全、有效的微创治疗技术。目的:综述椎体成形中骨充材料的生物力学性能、骨强度维持状态、骨降解吸收及诱导成骨等方面的研究进展。方法:第一作者应用计算机检索中国知网、PubMed、Medline数据库2005年1月至2016年5月的相关文章,英文检索词为"Bone cement;Bone filling materials;Percutaneous vertebroplasty",中文检索词为"骨水泥;骨填充材料;椎体成形术"。结果与结论:聚甲基丙烯酸甲酯骨水泥不是骨质疏松性椎体压缩骨折椎体填充的理想材料。磷酸钙骨水泥和硫酸钙骨水泥可替代传统聚甲基丙烯酸甲酯骨水泥,但磷酸钙骨水泥和硫酸钙骨水泥也存在一些问题,如显影效果不理想、生物降解速度难以控制、远期效果缺乏进一步循证医学的支持等。复合骨水泥兼顾了多种骨水泥的优点,是良好的骨修复材料,但进入临床时间短,还需大量的临床实践证明,是目前研究的主要方向。BACKGROUND： As a minimally invasive technology, percutaneous vertebroplasty is a safe and effective treatment for osteoporotic vertebral compression fractures. OBJECTIVE： To overview the research progress concerning the biomechanical properties, bone strength maintenance, bone absorption and degradation of bone filling materials used in percutaneous vertebroplasty. METHODS： The first author conducted a computer-based retrieval of CNKI, PubMed and Medline databases for relevant articles published from January 2005 to May 2016. The keywords were ＂bone cement, bone filling materials, percutaneous vertebroplasty＂ in English and Chinese, respectively. RESULTS AND CONCLUSION： Polymethyl methacrylate is not an ideal material for osteoporotic vertebral compression fractures. Calcium phosphate cement and calcium sulfate cement can replace the traditional polymethyl methacrylate; however, some problems still exist, such as poor effect of venography, incontrollable biological degradation rate, and lack of the evidence-based medicine about its long-term effect. Composite bone cement, as a good bone repair material, holds the advantages of various bone cements. As the composite bone cement has just been introduced in clinical practice, its long-term curative efficacy needs to be further studied.

关 键 词：椎体成形术 磷酸钙类 组织工程 生物材料 骨生物材料 聚甲基丙烯酸甲酯骨水泥 磷酸钙骨水泥 硫酸钙骨水泥 复合骨水泥 骨水泥 骨填充材料 

分 类 号：R318[医药卫生—生物医学工程]