置入碳纤维增强聚醚醚酮股骨头假体稳定性的生物力学分析  

Carbon fiber-reinforced polyetgeretherketone for femoral head prosthesis and its stability: a biomechanical analysis

作　　者：纪志华[1] 贾丙申[1] 周立义[1] 付昆[1] 孟志斌[1] 于鹏[1] 云大科 

机构地区：[1]海南医学院第一附属医院,海南省海口市570102

出　　处：《中国组织工程研究》2017年第15期2325-2330,共6页Chinese Journal of Tissue Engineering Research

基　　金：海南省自然科学基金资助项目(814357)~~

摘　　要：背景:在关节置换领域里,金属合金材料始终处于主导地位,但这种材料的最大缺陷是弹性模量高,由此产生应力遮挡,进而引起骨吸收、骨萎缩甚至假体松动等一系列并发症。碳纤维增强聚醚醚酮复合材料是各向异性材料,可以达到低弹高强,应用于制备人工假体有许多优势。目的:探讨碳纤维增强聚醚醚酮复合材料的血液相容性,并比较了碳纤维增强聚醚醚酮复合材料股骨头假体和钴铬钼合金股骨头假体置换后的生物力学特性。方法:(1)以溶血实验评价碳纤维增强聚醚醚酮复合材料的血液相容性;(2)收集8对新鲜成人尸体股骨标本,随机分为碳纤维增强聚醚醚酮假体组和钴铬钼合金假体组进行相应假体置换,测量加载200,400,600,800,1 000 N负荷下假体与骨之间的微动量,并检测假体置换后的抗扭转强度。结果与结论:(1)以碳纤维增强聚醚醚酮复合材料的溶血率为3.23%<5%,符合国家医疗器械生物学评价标准;(2)2组假体远端微动均明显小于近端(P<0.05);不同负荷下钴铬钼合金假体组远端、近端的微动量均显著大于碳纤维增强聚醚醚酮假体组(P<0.05);(3)碳纤维增强聚醚醚酮假体组不同负荷下的载荷-扭角均显著小于钴铬钼合金假体组(P<0.05),抗扭刚度均显著大于钴铬钼合金假体组(P<0.05);(4)结果说明碳纤维增强聚醚醚酮复合材料血液相容性较好,具有较好的稳定性,可用于假体置换。BACKGROUND： Metal implants have been extensively applied in joint arthoplasty, but the stress shielding effect caused by its high elastic modulus results in a series of complications, such as bone resorption, bone atrophy and prosthesis loosening. Carbon fiber-reinforced polyetheretherketone （CF-PEEK） composites are anisotropic and exhibit more advantages used for prosthesis due to its low elastic modulus and high intensity.OBJECTIVE： To investigate the blood compatibility of CF-PEEK composites, and compare the biomechanical properties after arthroplasty between CF-PEEK composites and Co-Cr-Mo used for femoral head prosthesis. METHODS： （1） The blood compatibility of CF-PEEK composites was evaluated through hemolysis test. （2） Femoral samples from eight fresh cadavers were collected and randomly divided into two groups, followed by subjected to CF-PEEK and Co-Cr-Mo prosthesis replacement, respectively. The displacement between the prosthesis and bone was measured under loading 200, 400, 600, 800 and 1000 N, and the torsional strength after arthroplasty was detected.RESULTS AND CONCLUSION： （1） The hemolysis rate of the CF-PEEK composites was 3.23% 〈 5%, which was in line with the national standards for biological evaluation of medical devices. （2） The micromovement in distal prosthesis was significantly less than that of proximal prosthesis under different loads in both two groups （P 〈 0.05）. （3） The torsion angle under different loads in the CF-PEEK group was significantly less than that in the Co-Cr-Mo group （P 〈 0.05）, and the torsion stiffness in the CF-PEEK group was significantly higher than that in the Co-Cr-Mo group （P 〈 0.05）. （4） To conclude,the CF-PEEK composites possess good blood compatibility and stability, which can be used as a prosthesis material.

关 键 词：钴铬钼合金 生物假体 组织工程 骨科植入物 人工假体 股骨头 关节假体 关节置换 碳纤维增强聚醚醚酮 复合材料 血液相容性 稳定性 海南省自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]