Genetically modifying transcription factors to promote CNS axon regeneration  

作　　者：Saloni T.Mehta John L.Bixby Vance P.Lemmon 

机构地区：[1]Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, USA [2]Center for Computational Science, University of Miami Miller School of Medicine, Miami, FL, USA [3]Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA [4]Molecular & Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA

出　　处：《Neural Regeneration Research》2017年第5期737-738,共2页中国神经再生研究（英文版）

基　　金：supported by NIH HD057632 to VPL and JLB.VPL holds the Walter G.Ross Distinguished Chair in Developmental Neuroscience

摘　　要：Following injury to the central nervous system（CNS）,severed axons fail to regenerate and re-form functional connections.Accordingly,CNS neurons appear to lack the intrinsic ability to modify their gene expression patterns to activate a robust regenerative response,perhaps as a result of limited plasticity in the adult brain（Davis,2013）.On the other hand,Following injury to the central nervous system（CNS）,severed axons fail to regenerate and re-form functional connections.Accordingly,CNS neurons appear to lack the intrinsic ability to modify their gene expression patterns to activate a robust regenerative response,perhaps as a result of limited plasticity in the adult brain（Davis,2013）.On the other hand,

关 键 词：CNS gene JUN VP 

分 类 号：R338[医药卫生—人体生理学]