家族性高胆固醇血症患者颈动脉内中膜厚度的危险因素分析  

Analysis of Risk Factors to Carotid Intima-Medial Thickness in Family Hypercholesterolemia Patients

作　　者：林利[1] 金雅磊[2] 程新耀[3] 

机构地区：[1]中国人民解放军武汉总医院超声影像科,湖北武汉430070 [2]武汉大学中南医院老年病科,湖北武汉430071 [3]武汉大学中南医院心血管内科超声心动图室,湖北武汉430071

出　　处：《武汉大学学报（医学版）》2017年第4期614-617,646,共5页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助项目(编号:81571754)

摘　　要：目的:观察家族性高胆固醇血症(FH)患者常见危险因素与动脉粥样硬化的相关程度。方法:FH患者14例,男6例,女8例,年龄8-65(37.68±19.00)岁,经基因筛查确证后收集临床资料如年龄、血压(SBP、DBP)、心绞痛、心电图结果,以及血脂等生化检查结果(TC、TG、HDL、LDL、APOB、GLU),超声测量双侧颈内动脉、颈动脉窦、颈总动脉最大厚度和最大平均厚度,对结果行多因素相关分析处理。结果:左/右侧颈动脉平均内中膜厚度与各参数的相关系数(P值)分别为,年龄:0.25/0.47(0.30/0.04),TC:0.87/0.77(均P<0.05),TG:0.81/0.72(均P<0.05),HDL:-0.71/-0.49(均P<0.05),LDL:0.87/0.79(均P<0.05),APOB:0.86/0.76(均P<0.05),GLU:-0.21/-0.08(0.40/-0.09),SBP:0.32/0.51(0.18/0.040),DBP:0.34/0.43(0.16/0.07);心绞痛:0.86/0.47(0.00/0.44),心电图:0.55/0.62(均P<0.05)。结论:FH患者动脉粥样硬化程度与血脂水平相关最密切,降脂是其根本防治措施。Objective： To compare the pathological importance among routine risk factors of atherosclerosis in familial hypercholesterolemia （FH） patients. Methods： Clinical investigations were done for 14 patients with familial hypercholesterolemia, 6 males and 8 females, age 37.68±19（8-65） years, the clinic data were collected including the history, life style, symptoms, physical signs, laboratory tests（such as blood lipid indices： TC, TG, HDL, LDL, APOB, GLV, ETC. ）, elec- trocardiographic and trans-precordial ultrasonic detections as well as carotid intima-medial thick- ness measurement. The data were analyzed using multiple linear regression analysis. Results： Coefficients （P values） between the risk factors and left/right average carotid intima-medial thickhess were respectively as age 0. 25/0. 47（0. 30/0. 04）,TC 0. 87/0. 77（both P〈0.05）,TG 0.81/0.72（both P〈0.05）, HDL- 0. 71/-0.49 （both P〈0.05）, LDL 0.87/0.79 （both P〈0.05）, APOB 0. 86/0. 76（both P〈0.05）,GLU -0.21/-0.08（0.40/-0.09）,SBP 0. 32/0. 51（0. 18/ 0.040） ,DBP 0.34/0.43 （0.16/0.07）, angina pectoris 0. 86/0. 47（0. 00/0. 44） ,and ECG ischemic changes 0.55/0.62 （both P〈0.05）. Conclusion. The blood lipid level was the closest correlative pathological factor of the atherosclerosis in familial hypercholesterolemia patients.

关 键 词：动脉粥样硬化 家族性高胆固醇血症 颈动脉内中膜厚度 

分 类 号：R589.2[医药卫生—内分泌]