Recent catalytic syntheses of trifluoromethylthio-containing organic compounds by transition metals,chiral organocatalysts,and photocatalysts  

作　　者：Yong Guo Mei-Wei Huang Xiao-Lin Fu Chao Liu Qing-Yun Chen Zhi-Gang Zhao Ben-Zhong Zeng Jiong Chen 

机构地区：[1]Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [2]College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China [3]Zhonghao Chenguang Research Institute of Chemical Industry, Zigong 643201, China

出　　处：《Chinese Chemical Letters》2017年第4期719-728,共10页中国化学快报（英文版）

基　　金：Support of our work by National Basic Research Program of China(973 Program,No.2012CB821600);National Natural Science Foundation of China(Nos.21421002,21172241,21302207,21672239)

摘　　要：This review summarizes the recent advances in the catalytic syntheses of CFS-containing organic molecules using various nucleophilic or electrophilic trifluoromethylthiolating reagents.C-halogen and C—H bonds in various molecules have been transformed to C—SCFbonds by transition-metal-catalyzed reactions,such as cross-coupling of aryl halides.Enantioselective reactions controlled by chiral metal complexes or chiral organocatalysts have afforded many trifluoromethylthiolated chiral architectures,such as β-ketoesters and oxindoles.Very recently,visible-light-induced photoredox trifluoromethylthiolations have been developed,providing versatile CFS-containing structures efficiently.This review summarizes the recent advances in the catalytic syntheses of CF_3S-containing organic molecules using various nucleophilic or electrophilic trifluoromethylthiolating reagents.C-halogen and C—H bonds in various molecules have been transformed to C—SCF_3 bonds by transition-metal-catalyzed reactions,such as cross-coupling of aryl halides.Enantioselective reactions controlled by chiral metal complexes or chiral organocatalysts have afforded many trifluoromethylthiolated chiral architectures,such as β-ketoesters and oxindoles.Very recently,visible-light-induced photoredox trifluoromethylthiolations have been developed,providing versatile CF_3S-containing structures efficiently.

关 键 词：Trifluoromethylthiolation Catalysis Transition metal Chiral Photoredox 

分 类 号：O621.3[理学—有机化学]