Wettability regulated gram-negative bacterial adhesion on biomimetic hierarchical structures  

作　　者：You Jiang Yi-Jie Yin Xin-Cheng Zha Xiao-Qiu Dou Chuan-Liang Feng 

机构地区：[1]State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, China

出　　处：《Chinese Chemical Letters》2017年第4期813-817,共5页中国化学快报（英文版）

基　　金：the NSFC(Nos.51273111,51173105,51573092);the National Basic Research Program of China(973 Program,No.2012CB933803);SJTU-UM Collaborative Research Program,the Program for Professor of Special Appointment(Eastern Scholar)at the Shanghai Institutions of Higher Learning

摘　　要：One of the critical issues in gram-negative bacterial adhesion is how wettability regulates adhesion as the surface wettability varies from superhydrophilic to superhydrophobic,and what is the relevant/contributing role of the lipopolysaccharide（LPS） outer layer of the gram-negative shell during this procedure.Herein,by avoiding the unexpected influence induced by the varied topographies,control over gram-negative bacteria adhesion by wettability is achieved on biomimetic hierarchical surfaces,which is mainly mediated by LPS layer.The study provides a methodology to have a good control over bacteria cell adhesion by properly designing wettable surface structures.This design concept is helpful for developing new generations of biomaterials in order to control a variety of diseases induced by gramnegative bacteria,which still continue to be very important and necessary in the fields of biomedicine.One of the critical issues in gram-negative bacterial adhesion is how wettability regulates adhesion as the surface wettability varies from superhydrophilic to superhydrophobic,and what is the relevant/contributing role of the lipopolysaccharide（LPS） outer layer of the gram-negative shell during this procedure.Herein,by avoiding the unexpected influence induced by the varied topographies,control over gram-negative bacteria adhesion by wettability is achieved on biomimetic hierarchical surfaces,which is mainly mediated by LPS layer.The study provides a methodology to have a good control over bacteria cell adhesion by properly designing wettable surface structures.This design concept is helpful for developing new generations of biomaterials in order to control a variety of diseases induced by gramnegative bacteria,which still continue to be very important and necessary in the fields of biomedicine.

关 键 词：Wettability Gelator Self-assembly Hierarchical structures Bacteria adhesion 

分 类 号：Q811[生物学—生物工程]