脊髓灰质炎后综合征的概念及病理生理机制  

Concept and Pathophysiology of Post-polio Syndrome(review)

作　　者：张爱民[1] 王玉明[2,3] 宫慧明[2,3] 张俊义 孙青[2] 张然[2] 李晶[2] ZHANG Ai-min WANG Yu-ming GONG Hui-ming ZHANG Jun-yi SUN Qing ZHANG Ran LI Jing(Research Institute of Rehabilitation Information, China Rehabilitation Research Center, Beijing 100068, China Department of Spinal and Neural Functional Reconstruction, Beijing Bo＇ai Hospital, China Rehabilitation Research Center, Beijing 100068, China Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China Dongsheng People＇s Hospital, Erdos, Inner Mongolia 017000, China)

机构地区：[1]中国康复研究中心康复信息研究所,北京市100068 [2]中国康复研究中心北京博爱医院脊柱脊髓神经功能重建科,北京市100068 [3]首都医科大学康复医学院,北京市100068 [4]东胜区人民医院,内蒙古鄂尔多斯市017000

出　　处：《中国康复理论与实践》2017年第5期497-500,共4页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：脊髓灰质炎后综合征(PPS)是患者急性感染脊髓灰质炎病毒,经过后遗症期后新发生的综合征。PPS发病率高,老年患者越来越多。PPS患者有累及肌肉的慢性神经源性损害,导致疲劳、疼痛、呼吸和睡眠障碍以及跌倒风险等,严重时影响健康状况和生活质量。PPS的发病机制有运动神经元过度负荷学说、脊髓灰质炎病毒持续存在学说等。PPS是一种相对稳定、缓慢进展的神经肌肉疾病。Post-polio syndrome （PPS） is a syndrome after acute infection of poliovirus and sequelae of polio. The incidence of PPS is high, and more in old patients. The pathological features of PPS include chronic nerve damage affected muscles, result in fatigue, pain, breathing and sleep disorders, fall risk, and so on, which impair their health and quality of life. The hypotheses of pathogenesis of PPS in- clude over load of motor neurons, and the continuous existence of the poliovirus, etc. PPS is a stable neuromuscular disease progressing slowly.

关 键 词：脊髓灰质炎后综合征 病理生理 综述 

分 类 号：R512.4[医药卫生—内科学]