短链脂肪酸在疾病治疗中的研究进展  

Role of short-chain fatty acids in disease treatment

作　　者：王璐璇[1] 刘玥宏[1] 朱继开 钟煜[1] 李利生[2] 徐敬东[3] 

机构地区：[1]北京市首都医科大学 [2]北京市首都医科大学机能实验平台中心,北京市100069 [3]北京市首都医科大学生理学与病理生理学系,北京市100069

出　　处：《世界华人消化杂志》2017年第13期1179-1186,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目,Nos.81274173,81673671,81270443;北京市自然科学基金资助项目,No.7122017~~

摘　　要：肠道内短链脂肪酸(short-chain fatty acids,SCFAs)浓度很高.他们是微生物自身以及宿主肠上皮细胞(intestinal epithelial cells,IESs)的能量来源,促进细胞生长,降低结肠内环境pH值,减少有害菌生长.近年研究证实,SCFAs能够调节宿主肠道免疫力,降低结肠炎症反应;抑制结肠肿瘤细胞增殖、诱导肿瘤细胞分化和凋亡、影响原癌基因表达.本综述将详述SCFAs通过G蛋白偶联受体激活途径和组蛋白去乙酰化酶抑制途径,引起中性粒细胞和调节性T细胞应答,降低结肠炎;增强IESs屏障功能;抑制结肠肿瘤增殖;治疗非酒精性脂肪性肝病和肥胖.Short chain fatty acids （SCFAs） are found in the intestine at high concentrations. In addition to acting as local substrates for energy production to promote cell growth, reduce environmental pH value in the colon, and reduce the growth of harmful bacteria, SCFAs can also regulate host physiology and immunity, suppress colon neoplasm cell proliferation by inducing their apoptosis and differentiation, and affect proto- oncogene expression. In this review, we discuss how SCFAs interact with G protein-coupled receptors to inhibit histone deacetyltransferase and thereby cause response of neutrophils and regulatory T cells to regulate intestinal immune responses and host physiological function. SCFAs can strengthen the epithelial barrier,suppress colon neoplasm cell proliferation, and be used to treat nonalcoholic fatty liver disease and obesity.

关 键 词：肠道内短链脂肪酸 肠道炎症 肠上皮细胞屏障功能 结肠肿瘤 非酒精性脂肪性肝病 肥胖 

分 类 号：R45[医药卫生—治疗学]