幽门螺杆菌感染与心血管疾病  

Helicobacter pylori infection and cardiovascular disease

作　　者：赵丽梅[1] 冯志杰[1] 

机构地区：[1]河北医科大学第二医院消化内科,河北省石家庄市050000

出　　处：《世界华人消化杂志》2017年第14期1255-1264,共10页World Chinese Journal of Digestology

摘　　要：随着社会经济的发展与生活方式的改变,心血管疾病的发生率明显上升,相关的危险因素包括年龄、吸烟、肥胖、糖尿病、高血压和血脂异常等,但仍有一部分心血管疾病尚未发现确切病因.近年来,随着幽门螺杆菌(Helicobacter pylori,H.pylori)研究的不断深入,发现其与多种胃肠外疾病的发生发展密切相关.目前国内外多项研究探讨了H.pylori感染与心血管疾病的相关性,多数研究认为心血管疾病患者H.pylori感染率明显增加,联合H.pylori根除治疗有益于心血管疾病的防治,但也有结果并不完全一致.本文就心血管疾病中H.pylori感染的研究现状,根除H.pylori对心血管疾病的影响以及H.pylori感染诱导心血管疾病的机制等方面的相关研究作一综述.With the development of social economy and the change in life style, the incidence of cardiovascular disease has obviously risen. Related risk factors include age, smoking, obesity, diabetes, hypertension and dyslipidemia. However, the etiology of certain cardiovascular diseases is largely unknown. In recent years, it has been found that Helicobacter pylori （H. pylori） infection is closely related to the occurrence and development of a variety of extra-gastrointestinal diseases. Many studies have explored the relationship between H. pylori infection and cardiovascular disease and suggested that H. pylori infection rate in patients with cardiovascular disease increases significantly. In addition, H. pylori eradication treatment is beneficial to the prevention of cardiovascular disease. However, there are still inconsistent results. In this paper, we will discuss the relationship between H. pylori infection and cardiovascular disease, highlighting the impact of H. pylori eradication on cardiovascular disease and the mechanism for H. pylori infection to induce cardiovascular disease.

关 键 词：幽门螺杆菌 心血管疾病 细胞毒素相关蛋白 机制 

分 类 号：R54[医药卫生—心血管疾病] R573[医药卫生—内科学]