美辛唑酮栓联合手术治疗肛窦炎伴肛乳头肥大临床疗效评价  

Clinical Evaluation of Indometacin and Furazolidone Suppositories Combined with Operation for Treating Anal Sinusitis with Anal Papilla Hypertrophy

作　　者：易成[1] 

机构地区：[1]四川省金堂县第一人民医院.四川大学华西医院金堂医院,四川成都610400

出　　处：《中国药业》2017年第9期44-46,共3页China Pharmaceuticals

摘　　要：目的探讨美辛唑酮栓联合肛窦切开并肛腺切除术治疗肛窦炎伴肛乳头肥大的临床疗效。方法选择医院2014年1月至2016年1月收治的肛窦炎伴肛乳头肥大患者120例,随机分为对照组与观察组,各60例。两组患者均行肛窦切开并肛腺切除术治疗,对照组患者术后采用Ⅲ型安尔碘消毒肛周、肛管及直肠等处,每日3次;观察组在对照组治疗基础上采用美辛唑酮栓治疗,于每晚睡前纳肛,每日1次,连续使用4周。采用疼痛视觉模拟评分(VAS)法评价疼痛程度,通过问卷调查评价肛门潮湿程度、肛门不适程度积分。随访6个月,比较两组患者的平均治愈时间、术后治愈患者复发情况。结果治疗后,两组患者VAS评分明显低于治疗前(P<0.01),观察组患者VAS评分为(0.75±0.34)分,明显低于对照组的(1.76±0.63)分(t=10.92,P=0.00);治疗后,两组患者肛门潮湿、肛门不适程度积分均明显低于治疗前(P<0.05),观察组肛门潮湿程度评分为(0.52±0.29)分,明显低于对照组的(0.89±0.51)分(P<0.05);观察组肛门不适程度积分为(0.85±0.35)分,明显低于对照组的(1.18±0.68)分(P<0.05);观察组平均治愈时间为(10.07±1.75)d,明显短于对照组的(15.86±2.38)d(t=15.18,P=0.00);观察组治愈后复发率为2.63%,明显低于对照组的21.43%(χ~2=6.00,P=0.01);观察组临床总有效率为91.67%,明显高于对照组的68.33%(χ~2=10.21,P=0.00)。结论肛窦切开并肛腺切除术联合美辛唑酮栓治疗肛窦炎伴肛乳头肥大的临床效果显著,有利于改善症状,减轻疼痛,同时还可减少术后复发,促进术后病情康复。Objective To explore the curative effect of anal sinus incision and anal gland resection combined with Indometacin and Furazolidone Suppositories for treating anal sinusitis with anal papilla hypertrophy. Methods Totally 120 patients with anal sinusitis and anal papilla hypertrophy from January 2014 to January 2016 were selected and randomly divided into the control group and the observation group, 60 cases in each group. The control group was treated with type m aneriodine for perianal, anal canal and rectum 3 times a day, on this basis, the observation group was added Indometacin and Furazolidone Suppositoriesb, which was inserted into the patients＇ anus before going to bed daily, 1 times a day, for 4 weeks. The visual analogue scale（VAS） was used to evaluate the degree of pain. The anal wetness and anal discomfort were evaluated by questionnaire. The average cure time was followed up for 6 months. The recurrence rate of the cured patients was recorded. Results After treatment, the VAS scores of the two groups were significantly lower than those before treatment（P 〈 0.01）,the VAS score in the observation group was （0. 75 ＋0.34） points, which was significantly lower than（1.76 -＋0. 63） points in the control group（ t = 10. 92, P =0. 00）. After treatment, the anal wet score and anal discomfort in the two groups were significantly lower than those before treatment（ P 〈 0.05）. The score of anal wet in the observation group was （0. 52 ± 0. 29） points, which significantly lower than （0.89±0. 51） points in the control group（P 〈 0.05）. The score of anal discomfort in the observation group was （0.85 ±0.35） points, which significantly lower than （1.18±0.68） points in the control group（P 〈 0.05）.The average healing time of the observation group was （10.07 ±1.75）d, which was significantly shorter than （15.86 ±2.38）d of the control group （t= 15. 18, P=0. 00）. The recurrence rate of the observation group was 2.63%,which was significantly lower than

关 键 词：肛窦炎 肛窦切开术 肛腺切除术 美辛唑酮栓 疼痛 复发 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R605[医药卫生—药学]