右美托咪定腰硬联合麻醉用于子宫肌瘤切除术镇静效果评价  

Sedative Effect of Using Dexmedetomidine in Combined Spinal Epidural Anesthesia in Resection of Myomectomy

作　　者：巨长桥[1] 刘德民[1] 张琦[1] 马莉[1] 

机构地区：[1]牡丹江医学院第二附属医院,黑龙江牡丹江157000

出　　处：《中国药业》2017年第9期65-67,共3页China Pharmaceuticals

摘　　要：目的探讨右美托咪定腰硬联合麻醉用于子宫肌瘤切除术的镇静效果。方法将2015年5月至2016年10月收治的子宫肌瘤切除术患者48例随机分两组,各24例。丙泊酚组在子宫肌瘤切除术治疗过程进行丙泊酚腰硬联合麻醉,右美托咪定组在子宫肌瘤切除术治疗过程进行右美托咪定腰硬联合麻醉。比较两组患者麻醉镇静总有效率,子宫肌瘤切除术中低血压、心动过缓、疼痛呻吟、烦躁不安等不良事件的发生率,麻醉前和手术开展0.5 h患者心率、镇静评分、脑电双频指数的差异。结果右美托咪定组患者麻醉镇静总有效率为95.83%,明显高于丙泊酚组的75.00%(P<0.05);右美托咪定组子宫肌瘤切除术中低血压、心动过缓、疼痛呻吟、烦躁不安等不良事件的发生率低于丙泊酚组(P<0.05);麻醉前,两组患者的心率、镇静评分、脑电双频指数比较无显著差异(P>0.05),手术开展0.5 h右美托咪定组各指标显著优于丙泊酚组(P<0.05)。结论右美托咪定腰硬联合麻醉用于子宫肌瘤切除术的镇静效果确切,可有效维持术中生命体征的平稳,发挥良好的镇静作用,减少不良事件的发生,值得临床推广。Objective To investigate the sedative effect of using Dexmedetomidine in combined spinal epidural anesthesia（CSEA） in the resection of myomectomy. Methods Totally 48 patients with the resection of myomectomy from May 2015 to October 2016 were randomly divided into two groups. In the resection of myomectomy, the Propofol group was treated with Propofol in CSEA, the Dexmedetomi- dine group was treated with Dexmedetomidine in CSEA. The total effective rate of anesthesia sedation , the adverse events（such as low blood pressure, bradycardia, pain groan, irritability and others）, the difference of heart rate, sedation score and bispectral index in patients undergoing anesthesia before and 0.5 hour after operation in the two groups were compared. Results The total effective rate of anesthesia sedation in the Dexmedetomidine group was 95.83%, which was significantly higher than 75.00% of the Propofol group（P 〈 0.05）. The incidence rate of adverse events was significantly lower than those of the Propofol group（P 〈 0. 05）. Before treatment, the heart rate, sedation score and bispectral index between the two groups showed no significant difference（ P 〉 0.05）, 0. 5 h after operation, those in the Dexmedetomidine group was significantly better than those of the Propofol group（P 〈 0. 05）. Conclusion The effect of Dexmedetomidine on the myomectomy resection is effective, it can effectively maintain the vital signs of operation and has sedative ef- fect. It can reduce the occurrence of adverse events, which is worthy of clinical promotion.

关 键 词：右美托咪定 腰硬联合麻醉 子宫肌瘤切除术 镇静 

分 类 号：R969.4[医药卫生—药理学] R971.2[医药卫生—药学]