Beclin1基因在消化道肿瘤发生发展中的作用及其影响因素研究进展  

Research Progress in Influential Factors of Beclin 1 and Its Role in Occurrence and Development of Gastrointestinal Tumor

作　　者：冯巍巍[1] 黄桂柳 季科[1] 黄赞松[1,2] 覃月秋[2] 

机构地区：[1]右江民族医学院研究生学院,广西百色533000 [2]右江民族医学院消化病研究所右江民族医学院附属医院消化内科,广西百色533000

出　　处：《医学综述》2017年第10期1923-1928,共6页Medical Recapitulate

基　　金：广西自然科学基金(桂财教2014GXNSFAA118143;桂科自0542119);广西高校优秀人才资助计划(桂教人RC2007029);广西医疗卫生重点科研课题(桂卫重200887);2016年广西硕士研究生创新计划(201601004);广西高校右江流域特色民族医药研究重点实验室开放课题(kfkt2016025)

摘　　要：自噬是一种高度保守的溶酶体降解的过程,其能降解细胞中受损的细胞器和错误折叠蛋白,以维持细胞内环境稳定,自噬对肿瘤具有双重作用,其既能为肿瘤细胞提供营养和保护,又可抑制或杀伤肿瘤细胞,而Beclin1是重要的自噬相关基因,其在肿瘤的发生发展中可调节自噬状态,其表达改变可影响肿瘤发生发展,并与化疗耐药相关。了解Beclin1的结构、作用机制、影响因素以及与消化道肿瘤的关系,将会为消化道肿瘤的检测、诊断、治疗、预后提供新策略。Autophagy, a highly conserved lysosomal degradation process, can degrade misfolded proteins and impaired organelles to stabilize intracellular environment in cells. Autophagy has a dual role in cancer, which can not only provide nutrition and protection for tumor cells, but also inhibit the growth of tumor cells or kill them. A key autophagy-related gene Beclinl may regulate autophagic state in cancer formation and progression. Changes in its expression can affect occurrence and development of tumor, and it is related to chemotherapeutic drug resistance. Better understanding of Beclinl＇s structure, function, influencing factors and relations with gastrointestinal tumor, may provide new strategies for the detection, diagnosis, treatment and prognosis of gastrointestinal tumor.

关 键 词：消化道肿瘤 自噬 自噬基因 BECLIN1 

分 类 号：R735[医药卫生—肿瘤]