痰热清注射液治疗风热型急性气管-支气管炎临床疗效及其机制研究  

Clinical Effect of Tanreqing Injection on Treating Acute Bronchitis/Bronchiolitis and Its Mechanism Research

作　　者：李文[1] 刘波 郑玉琼[1] 周维[1] 王慧[1] 刘亮[1] 毛振新 周雨[1] 杨萍[1] 

机构地区：[1]成都市中西医结合医院,四川成都610041 [2]四川省中医药学会,四川成都610041

出　　处：《四川中医》2017年第4期193-198,共6页Journal of Sichuan of Traditional Chinese Medicine

基　　金：成都市科技计划项目(编号:10YTY291SF-182)

摘　　要：目的:本试验通过观察痰热清注射液治疗风热型急性气管-支气管炎(acute bronchitis/bronchiolitis,ABB)患者的临床疗效,并对其治疗机制进行初步探讨。方法:采用随机对照临床试验(randomised controlled trial,RCT),选取风热型ABB患者120例,分为A、B两组,A组60例(对照组:常规西药治疗),B组60例(治疗组:在常规西药治疗基础上联合痰热清注射液20ml ivgtt qd)。治疗观察3天。观察两组治疗前后血浆IL-4、IL-8、IL-10水平、中医症候(症状:咳嗽、痰量、咳痰、发热、恶寒、口干;体征:舌象、脉象)改善水平,比较两种治疗方案的临床疗效,并进一步研究临床疗效的相关机制。结果:两组患者治疗前的临床症状及体征(咳嗽、痰量、咳痰、发热、恶寒、口干、舌象、脉象)比较无显著差异(P>0.05);组内比较:两组患者咳嗽、痰量、咳痰、发热、恶寒、口干、舌象、脉象在治疗前后均有显著差异(P<0.05或0.01);组间比较:治疗前后中医症状咳嗽、咳痰的差值比较B组明显高于A组(P<0.05),治疗3天后2组在发热、恶寒、口干、舌象、脉象方面的构成比有显著差异(P<0.05)。两组患者治疗前IL-4、IL-8、IL-10无显著差异(P>0.05);组内比较:两组患者在治疗前后血浆IL-4、IL-8、IL-10水平均有明显下降(P<0.05);组间比较:治疗前后IL-4、IL-8、IL-10的差值比较B组明显高于A组(P<0.05)。结论:痰热清注射液联合西药治疗较单纯西药治疗风热型ABB患者疗效显著,可使患者某些中医症候(如咳嗽、咳痰、发热、恶寒、口干、舌象、脉象)会有明显改善,其机制有可能与炎症介质如IL-4、IL-8、IL-10的下降有关。Objective： To observe the effect of Tanreqing Injection in wind-heat type ABB patients, and to research its mech- anism. Methods： In a prospective randomized controlled clinical trial, 120 patients with wind-heat type ABB were randomly and averagely assigned into the group A and group B. The group A received the conventional western medicine treatment; the group B received the intravenous fluid therapy of 20ml Tanreqing Injection once a day and the conventional western medicine treatment. The treatment was administered for 3 days. Chinese medical symptoms and signs were scored （cough, sputum volume, phlegm, fever, chills, dry mouth, tongue and pulse）, and plasma concentration of IL-4, IL-8, IL-10 were recorded. The clinical efficacy of the two kinds of treatment was compared and related mechanisms were studied. Results ： （ 1 ） Before treatment, there was no significant difference in the clinical symptoms and signs （cough, sputum volume, phlegm, fever, chills, dry mouth, tongue and pulse） between the group A and B （P 〉 0. 05）. In the group A and B, the cfinical symptoms and signs （ cough, sputum volume, phlegm, fever, chilis, dry mouth, tongue and pulse） were all significantly improved after treatment （P 〈 0. 05 ）. The differences of cough, phlegm before and after treatment were higher in the group B than that in the group A （ P 〈 0. 05 ）. There were more patients recovey in some respects such as fever, chills, dry mouth, tongue and pulse in the group B than that in the group A （ P 〈 0. 05 ）. （4） The plasma level of IL-4, IL-8, IL-10 had no difference between the group A and B before treatment （P 〉 0. 05）. In the group A and the group B, the plasma level of IL-4, IL-8, IL-10 were significantly decrease after treatment （ P 〈 0. 05）. Conclusion ： Comparing with pure western medicine treatment, Tanreqing Injection combined with western medicine therapy for patients with wind-heat type ABB has significantly curative effect, which mechanism may be related

关 键 词：痰热清注射液 急性气管-支气管炎 IL-4 IL-8 IL-10 

分 类 号：R562[医药卫生—呼吸系统]