塞来昔布联合布比卡因控制开颅手术术后疼痛的研究  

A study of combined use of celecoxib and bupivacaine for pain control after craniotomy

作　　者：韩铖琛[1] 杨帆[1] 魏铂沅[1] 王洪伟[1] 张剑宁[1] 

机构地区：[1]中国人民解放军海军总医院神经外科,北京100048

出　　处：《徐州医科大学学报》2017年第5期312-314,共3页Journal of Xuzhou Medical University

摘　　要：目的探讨塞来昔布联合布比卡因局部浸润麻醉控制神经外科开颅手术术后切121疼痛的效果。方法80例患者择期行开颅手术，随机分为4组，每组20例。对照组按时口服安慰剂；塞来昔布组术前口服塞来昔布（200mg／片）2片，随后每日2次各1片，持续3天；布比卡因组口服安慰剂，并于手术结束缝皮前切口周围以布比卡因全层浸润麻醉；塞来昔布联合布比卡因组（联合用药组）术前V1服塞来昔布，缝皮前切El周围以布比卡因全层浸润麻醉。观察各组术后各时段的VAS评分及不良反应等情况。结果联合用药组镇痛效果最好，VAS评分低于其他各组（P〈0．01）。无患者发生严重药物相关不良反应。结论塞来昔布联合布比卡因可以有效缓解术后疼痛，是较为理想的开颅手术术后镇痛方法。Objective To evaluate the effects of celecoxib combined with bupivacaine on the pain after craniotomy. Methods A total of 80 patients who underwent craniotomy were randomly divided into four groups （ n = 20 ） ： a control group orally administrated with placebo, a celecoxib group who orally took 2 tablets of celecoxib （ 200 mg per tablet, one tablet per time, twice per day for three consecutive days） before operation, and a bupivacaine group who was orally administrated with placebo and underwent infiltration anesthesia with bupivacaine before the end of surgery, and a combined group who orally took celecoxib before operation and underwent infiltration anesthesia with bupivacaine before the end of surgery. The VAS score of each group was evaluated at different time points, while adverse effects were recorded. Results The combined group showed the score of VAS which were lower than those in other groups （P 〈0. 01 ）. No serious drug - related adverse reaction was reported. Conclusion The combined use of celecoxib and bupivacaine can effectively relieved pain in patients after craniotomy.

关 键 词：开颅手术 镇痛 塞来昔布 布比卡因 

分 类 号：R441.1[医药卫生—诊断学] R651.11[医药卫生—临床医学]