碳纳米管结合人参皂苷Rb_1、Rb_2纳米乳经皮给药系统的制备  

Preparation of transdermal drug delivery system of carbon nanotubes graft ginsenosides Rb_1 and Rb_2 nanoemulsion

作　　者：曾臣红 王政[1] 陈冲[1] 魏莉[1] 

机构地区：[1]上海中医药大学,上海201203

出　　处：《中成药》2017年第6期1161-1164,共4页Chinese Traditional Patent Medicine

摘　　要：目的制备碳纳米管结合人参皂苷Rb_1、Rb_2纳米乳经皮给药系统。方法 0.5%碳纳米管加入已制备的纳米乳中,透射电镜观察其结合状态,考察该给药系统的皮肤刺激性和透皮机制。再建立小鼠皮肤UVA损伤模型,评价其抗氧化活性。结果碳纳米管对纳米乳具有很强的吸附作用,并在表皮层形成药物储库,从而增加人参皂苷Rb_1、Rb_2的透皮渗透量。给药系统组小鼠皮肤组织中SOD活性显著高于模型组和纳米乳组(P<0.01),MDA含有量显著减少(P<0.01)。结论碳纳米管结合人参皂苷Rb_1、Rb_2纳米乳经皮给药系统对皮肤刺激性小,并可使药物更好地透过皮肤以发挥抗氧化活性。AIM To prepare the transdermal drug delivery system of carbon nanotubes graft ginsenosides Rb1 and Rb2 nanoemulsion.METHODS After 0.5% carbon nanotubes’ dispersion into the prepared nanoemulsion,the combination state was observed under transmission electron microscope.The skin irritation and transdermal mechanism of this drug delivery system were investigated.Then the UVA-damaged mouse skin model was established to evaluate the antioxidant activity.RESULTS Carbon nanotubes had strong adsorption to nanoemulsion,together with the formation of drug storage cavern in epidermis,thus increased the transdermal osmotic quantities of ginsenosides Rb1 and Rb2.The SOD activity in mouse skin tissue in the drug delivery system group was higher than that in the model group and the nanoemulsion group（P〈0.01）,and the MDA content was significantly decreased（P〈0.01）.CONCLUSION The transdermal drug delivery system of carbon nanotubes graft ginsenosides Rb1 and Rb2nanoemulsion can make drugs play an antioxidant role because of its less irritation to skin and better skin permeability.

关 键 词：碳纳米管 人参皂苷RB1 人参皂苷Rb2 纳米乳 经皮给药系统 抗氧化活性 

分 类 号：R944[医药卫生—药剂学]