蝉翼藤化学成分的研究  

Chemical constituents from Securidaca inappendiculata

作　　者：王起文[1] 陈东东[1] 马程遥 李祥[1] 陈建伟[1] 

机构地区：[1]南京中医药大学,江苏南京210023

出　　处：《中成药》2017年第6期1199-1203,共5页Chinese Traditional Patent Medicine

基　　金：江苏高校优势学科建设工程资助项目(DE63063683)

摘　　要：目的研究蝉翼藤Securidaca inappendiculata Hassk.的化学成分。方法蝉翼藤95%乙醇提取物的二氯甲烷、乙酸乙酯部位采用硅胶、凝胶柱和重结晶进行分离纯化,根据理化性质和波谱数据鉴定所得化合物的结构。结果从中分离出10个化合物,分别鉴定为8-羟基-1,3,4-三甲氧基口山酮(1)、1,2,7-三甲氧基口山酮(2)、4-羟基-3,5-二甲氧基苯甲醛(3)、芝麻素(4)、2-甲氧基-3,4-亚甲二氧基二苯酮(5)、1,3,7-三羟基-4-甲氧基口山酮(6)、1,3,7-三羟基-2-甲氧基口山酮(7)、2-羟基-1,7-二甲氧基口山酮(8)、3,8-二羟基-1,4-二甲氧基口山酮(9)、α-菠菜甾醇(10)。结论化合物1为首次以天然产物形式被发现,化合物2~4为首次从蝉翼藤属植物中分离得到。AIM To study the chemical constituents from Securidaca inappendiculata Hassk..METHODS The dichloromethane and ethyl acetate fractions of S.inappendiculata 95% ethanol extract were isolated and purified by silica,gel column and recrystallization,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Ten compounds were isolated and identified as 8-hydroxy-1,3,4-trimethoxyxanthone（1）,1,2,7-trimethoxyxanth-one（2）,4-hydroxy-3,5-dimethoxybenzaldehyde（3）,sesamin（4）,2-methoxy-3,4-methylenedioxybenzophenone（5）,1,3,7-trihydroxy-4-methoxyxanthone（6）,1,3,7-t-rihydroxy-2-methoxyxanthone（7）,2-hydroxy-1,7-dimethoxyxanthone（8）,3,8-dih-ydroxy-1,4-dimethoxyxanthone（9）,α-spinasterol（10）.CONCLUSION Compound 1 is first found in the form of natural product,compounds 2-4 are isolated from genus Securidaca for the first time.

关 键 词：蝉翼藤 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]