甲状腺结节与尿酸水平的相关性及性别差异研究  

Research on the correlation between uric acid levels and thyroid nodules and gender differences

作　　者：刘瑶[1] 林紫薇[1] 盛春君[1] 邹大进[1] 吕中伟[1] 徐辉雄[1] 朱亦堃[2] 黄昀[1] 钟霓[1] 贾钊[2] 蒋酋 曲伸[1] 

机构地区：[1]上海第十人民医院内分泌与代谢病科,上海市第十人民医院甲状腺疾病研究中心,同济大学甲状腺疾病研究所,200072 [2]山西医科大学附属第二医院内分泌与代谢病科,太原030001

出　　处：《中华内分泌代谢杂志》2017年第5期377-381,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：市级医院新兴前沿技术联合攻关项目（SHDC12015127）

摘　　要：目的探讨甲状腺结节发病与尿酸水平的相关性及性别差异。方法选取2013年1月至2015年6月于山西地区体检中心体检者68056例为研究对象，其中男性33203例，女性34853例。记录体检者一般情况及各项指标，所有体检者均由专人行甲状腺彩超检测。结果（1）甲状腺结节总患病率为35．5％。其中男性患病率为30．7％，女性患病率为40．0％；单发结节患病率为50．1％，多发结节患病率为49．9％。（2）有结节组与无结节组相比较，有结节组年龄、体重指数、血压、三酰甘油、总胆固醇、低密度脂蛋白胆固醇明显高于无结节组，差异具有统计学意义（P〈0．01）；但有结节组尿酸水平低于无结节组，差异具有统计学意义（P〈0．01）。男性人群有结节组尿酸水平低于无结节组[（352．37±78．14对357．70±77．51）μmol／L，P〈0．01]，而女性人群有结节组尿酸水平高于无结节组[（260．22±61．91对253．91±59．18）μmol／L，P〈0．01]，差异具有统计学意义。结论甲状腺结节发病可能与代谢和炎症相关。尿酸水平在不同性别对甲状腺结节的发病具有不同的影响，在男性人群中，高尿酸血症组甲状腺结节患病率较低；而在女性人群中，高尿酸血症组甲状腺结节患病率较高。Objective To explore the correlation between thyroid nodules and uric acid levels and to find their gender differences. Methods A total of 68 056 subjects in a regional medical physical examination center of Shanxi Province from January 2013 to June 2015 were enrolled in this study. All the participants＇ general information and parameters were recorded. Thyroid nodules were detected by color Doppler uhrasonography. Results The total prevalence of thyroid nodule was 35.5%, 30.7% in males and 40.0% in females. The prevalence of single nodule was 50. 1 %, and multiple 49.9%. Compared with no nodule group, thyroid nodule group tended to be older, with higher BMI, and with a worse metabolic status（ all P〈0.01 ）. The uric acid levels were lower[ （ 352.37 ± 78. 14 vs 357.70 ± 77.51 ） μmol/L, P〈0.01 ] in thyroid nodule group in male and higher [ （260.22 ± 61.91 vs 253.91 ± 59.18） μmol/L, P〈0. 01 ] in female. Conclusion Thyroid nodules may be associated with metabolism and inflammation. In males, hyperuricemia group had lower, while in females, hyperuricemia ones were with a higher prevalence of thyroid nodules.

关 键 词：甲状腺结节 尿酸 代谢紊乱 性别差异 

分 类 号：R581[医药卫生—内分泌]